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聂辅娇,孙淑铭,谢鹤,李怡琛,宋焰,刘志敏,陈向东.养阴清热、活血利水方联合西药治疗糖尿病视网膜病变激光术后的疗效观察[J].湖南中医药大学学报英文版,2017,37(12):1381-1385.[Click to copy
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| 养阴清热、活血利水方联合西药治疗糖尿病视网膜病变激光术后的疗效观察 |
| 聂辅娇,孙淑铭,谢鹤,李怡琛,宋焰,刘志敏,陈向东 |
| (湖南中医药大学第一附属医院眼科, 湖南 长沙 410007) |
| 摘要: |
| 目的 观察养阴清热、活血利水中药复方联合抗血管内皮生长因子（vascular endothelial growth factor，VEGF）药物治疗糖尿病视网膜病变激光术后的临床疗效。方法 将视网膜激光光凝治疗的糖尿病视网膜病变患者60例，根据不同的治疗方法，分为抗VEGF药物治疗组（对照组）和养阴清热活血利水中药复方+抗VEGF药物治疗组（观察组），观察两组患者疗程结束后4周、半年的最佳矫正视力、黄斑中心凹厚度变化、中医症候、注射抗VEGF次数及总体疗效的情况，比较两种治疗方法的综合疗效。结果 疗程结束4周后，两组的视力、黄斑中心厚度、中医症候、总体疗效差异无统计学意义（P>0.05）；疗程结束半年后，观察组的视力、黄斑中心厚度、中医症候、总体疗效优于对照组，差异有统计学意义（P<0.05）；观察组注射抗VEGF次数明显少于对照组（P<0.05）。结论 养阴清热活血利水中药复方联合抗VEGF药物治疗糖尿病视网膜病变激光术后患者的远期疗效优于单纯抗VEGF药物治疗。 |
| 关键词: 糖尿病视网膜病变 激光光凝术 养阴清热活血利水方 抗VEGF药物 临床研究 |
| DOI：10.3969/j.issn.1674-070X.2017.12.020 |
| Received:July 11, 2017 |
| 基金项目:湖南省自然科学基金项目（2015JJ2109）；湖南省中医药科研计划项目（201463）；湖南省中医药管理局科研课题（2017141）；《中医眼科学》国家中医药管理局重点学科；《中医五官科学》湖南省重点学科。 |
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| Clinical Efficacy of Yangyin Qingre Huoxue Lishui Decoction Combined with Western Medicine in Treatment of Diabetic Retinopathy after Laser Surgery |
| NIE Fujiao,SUN Shuming,XIE He,LI Yichen,SONG Yan,LIU Zhimin,CHEN Xiangdong |
| (Department of Ophthalmology, the First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha. Hunan 410007, China) |
| Abstract: |
| Objective To analyze the clinical efficacy of Yangyin Qingre Huoxue Lishui decoction and anti-VEGF drugs in the treatment of diabetic retinopathy after laser surgery. Methods Using the retrospective case-control study, 60 patients with diabetic retinopathy treated by retinal laser photocoagulation from January 2016 to May 2017 were selected. According to different treatment methods, the patients were divided into two groups:anti vascular endothelial growth factor (VEGF) group (control group) and Yangyin Qingre Huoxue Lishui+anti-VEGF group (observation group). The best correction visual acuity, macular fovea thickness changes, TCM symptoms and the overall efficacy after 4 weeks and six months of treatment were observed. The comprehensive effect of the two groups were compared. assess the efficacy and safety of the two treatments. Results The best correction visual acuity, macular fovea thickness, TCM symptoms and overall efficacy of two groups were not statistically different after 4 weeks of treatment (P>0.05). The best correction visual acuity, macular fovea thickness, TCM symptoms and overall efficacy of the observation group were better than control group at half a year after the end of treatment, and the difference is statistically significant (P<0.05). Conclusion The long-term efficacy of Yangyin Qingre Huoxue Lishui decoction combined with anti-VEGF drugs is better than anti-VEGF drugs. |
| Key words: diabetic retinopathy laser photocoagulation Yangyin Qingre Huoxue Lishui decoction anti-VEGF drugs clinical study |
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