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吴彬才,王立凤,杨柳,袁振仪,毛以林,王净净.郭振球教授治疗原发性高血压病组方用药规律研究[J].湖南中医药大学学报英文版,2017,37(11):1243-1247.[Click to copy
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| 郭振球教授治疗原发性高血压病组方用药规律研究 |
| 吴彬才,王立凤,杨柳,袁振仪,毛以林,王净净 |
| (湖南中医药大学, 湖南 长沙 410208;湖南中医药大学第二附属医院, 湖南 长沙 410005) |
| 摘要: |
| 目的 应用中医传承辅助系统软件分析郭振球教授治疗原发性高血压病的用药及组方规律。方法 收集郭振球教授2007年9月-2009年3月治疗原发性高血压病的部分病例，录入"中医传承辅助平台（V2.5）"系统，采用系统中的药物频次统计分析及关联规则、改进互信息法、复杂系统熵聚类等无监督数据挖掘方法，总结郭教授治疗原发性高血压病的常用药物，分析方剂中的组方规律。结果 对纳入的49名原发性高血压患者，共91首处方进行分析，确定郭振球教授治疗原发性高血压病处方中药物有钩藤、天麻、菊花等150种，药物间核心组合模式多见天麻、菊花等药物与钩藤关联，挖掘演化得到14首治疗原发性高血压病的新处方。结论 数据挖掘法对于发现名老中医隐性临床经验具有重要实用价值，较好地体现了郭振球教授治疗原发性高血压病的用药规律，即多以平肝息风μ阴益肾、健脾化痰为主。 |
| 关键词: 原发性高血压病 数据挖掘 中医传承辅助平台 郭振球 |
| DOI：10.3969/j.issn.1674-070X.2017.11.018 |
| Received:July 05, 2016 |
| 基金项目:湖南省教育厅资助项目（14A110）；湖南中医药大学研究生创新课题资助项目（2015CX13）；湖南省精品课程“方剂学”资助项目。 |
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| Medication Rule of Professor Guo Zhenqiu in Treatment of Primary Hypertension |
| WU Bincai,WANG Lifeng,YANG Liu,YUAN Zhenyi,MAO Yilin,WANG Jingjing |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;The Second Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410005, China) |
| Abstract: |
| Objective To analyze medication and formula compatibility's rule of Prof. Guo Zhenqiu in the treatment of primary hypertension with Traditional Chinese Medicine Inheritance Support System (TCMISS). Methods Patients with primary hypertension treated by Prof. Guo Zhenqiu from September 2007 to March 2009 were entered into the TCMISS. The commonly used herbs and formula compatibility's rule of priamary hypertension treated by Prof. Guo were summarized through statistical analysis of herb frequency, the association rules, imroving the mutual information, complex system entropy clustering and other unsupervised data mining methods. Results The 91 prescriptions from 49 patients primary hypertension, the frequency of each herb appeareds in the database were calculated. There were 105 herbs were used for treatment of primary hypertension, such as Uncariae Ramulus Cum Uncis (Gouteng), Gastrodiae Rhizoma (Tianma), Juhua. The common core combinations were herbs, such as Tianma, Juhua, with Gouteng. Fourteen new prescriptions for different hypertension stage were discovered. Conclusion Data mining method has practical value for discovering experiences from famous TCM doctors. The method clearly shows the medication rules of Professor Guo Zhenqiu in treatment of primary hypertension, mainly based on calming the liver to stop the wind (Pinggan Xifeng), nourishing Yin and tonifying the kidney (Ziyin Yishen) and strengthening the spleen and reducing phlegm (Jianpi Huatan). |
| Key words: primary hypertension data mining traditional Chinese medicine inheritance support system Guo Zhenqiu |
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