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万宇翔,郑子安,白辰,王云辉,于河,刘铁钢,谷晓红.银莱汤对发热大鼠血清IL-1β、TNF-α、IL-6含量的影响[J].湖南中医药大学学报英文版,2017,37(11):1184-1187.[Click to copy
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| 银莱汤对发热大鼠血清IL-1β、TNF-α、IL-6含量的影响 |
| 万宇翔,郑子安,白辰,王云辉,于河,刘铁钢,谷晓红 |
| (北京中医药大学基础医学院, 北京 100029) |
| 摘要: |
| 目的 研究银莱汤对发热大鼠体温和血清IL-1β、TNF-α、IL-6含量的影响。方法 90只SD大鼠连续测温3次，选取合格大鼠背部皮下注射20%干酵母混悬液10 mL/kg建立大鼠发热模型，随机平均分为正常组、模型组、阿司匹林组、银莱汤高剂量组、银莱汤中剂量组、银莱汤低剂量组共6组，每组8只大鼠。分别于造模前0.5 h和造模后5 h两次灌胃给药，造模后每小时测温一次，于末次给药后3 h取血，通过ELISA和RIA方法检测血清中炎性介质白介素-1β（IL-1β）、白介素-6（IL-6）、肿瘤坏死因子α（TNF-α）含量水平。结果 银莱汤各剂量组体温均低于模型组（P<0.01），银莱汤各剂量组血清中IL-1β、TNF-α、IL-6含量均低于模型组（P<0.05）。结论 银莱汤对发热大鼠具有明显的退热效果，其作用机制可能与降低机体炎症反应，减少血清中IL-1β、TNF-α、IL-6的产生或加速降解相关。 |
| 关键词: 银莱汤 发热 炎症 IL-1β TNF-α IL-6 |
| DOI：10.3969/j.issn.1674-070X.2017.11.004 |
| Received:September 05, 2016 |
| 基金项目:国家自然科学基金项目（81403328）；北京市教委产学研项目（1000062520040）；北京中医药大学自主选题资助项目（2016-JYB-XS031）。 |
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| Effect of Yinlai Decoction on IL-1β, TNF-α, IL-6 Levels in Serum of Fever Rats |
| WAN Yuxiang,ZHENG Zian,BAI Chen,WANG Yunhui,YU He,LIU Tiegang,GU Xiaohong |
| (School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing 100029, China) |
| Abstract: |
| Objective To explore the effect of Yinlai decoction on body temperature, Serum Content of IL-1β, TNF-α, IL-6 of Fever Rats. Methods 90 male rats were randomly divided into normal group, model group, aspirin group, and high, middle and low dose Yinlai decoction groups, 8 rats in each group. Fever rat models were induced with dorsal hypodermic injection of 20% dry yeast suspension, and they were fed with leechdom half an hour before building the fever model and 5 hours after building the fever model. The blood were taken at the 8th hour after building the model. The levels of IL-6, IL-1β and TNF-α in serum were detected by ELISA and RIA. Results Temperature in different doses of Yinlai decoction groups are lower than the model group (P<0.01). The IL-1β, TNF-α, IL-6 levels in serum were significantly lower than those in the model group (P<0.05). Conclusion Yinlai decoction shows obvious anti-febrile effect on fever rats. Its mechanism may relate to restraining the inflammation reaction and reducing the expression of IL-1β, TNF-α, IL-6 in serum. |
| Key words: Yinlai decoction pyrexia inflammation IL-1β TNF-α IL-6 |
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