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章玉玲,杨涛,倪维.抗苗勒管激素、IL-21联合性激素检测在预测卵巢早衰中的诊断价值[J].湖南中医药大学学报英文版,2017,37(10):1110-1112.[Click to copy
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| 抗苗勒管激素、IL-21联合性激素检测在预测卵巢早衰中的诊断价值 |
| 章玉玲,杨涛,倪维 |
| (湖北省荆州市中医医院检验科, 湖北 荆州 434000;湖北省中医院检验科, 湖北 武汉 430000) |
| 摘要: |
| 目的 探讨血清抗苗勒管激素（AMH）、白细胞介素-21（IL-21）联合性激素检测在预测卵巢早衰（POF）中的诊断价值。方法 采用回顾性方法，选取我院2014年7月-2016年7月妇科病区收治的168例确诊POF的患者作为观察组，另选同时期100例月经周期、基础内分泌均正常的育龄健康体检妇女作为对照组。用放射免疫法测定抗苗勒管激素、IL-21，用化学发光的方法测定性激素六项。结果 观察组POF患者的血清抗苗勒管激素水平、雌二醇E2水平明显降低，差异有统计学意义（P<0.05）；IL-21升高，差异有统计学意义（P<0.05）；卵泡生成激素FSH、黄体生成激素LH较对照组明显升高，差异有统计学意义（P<0.05），而孕酮P、睾酮T、泌乳素PRL无显著性差异（P>0.05）。结论 抗苗勒管激素随着年龄增长而逐渐下降，是卵巢早衰的敏感指标，IL-21在POF观察组明显升高，可能与自身免疫有关，联合性激素检测，可提高POF的预测和诊断价值。 |
| 关键词: 卵巢早衰 抗苗勒管激素 白细胞介素-21 性激素 |
| DOI：10.3969/j.issn.1674-070X.2017.010.016 |
| Received:July 27, 2016 |
| 基金项目:国家自然科学基金项目（81573815）。 |
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| Diagnosis Value of Anti-Mullerian Hormone and IL-21 Combined with Sex Hormones Tests in Prediction of Premature Ovarian Failure |
| ZHANG Yuling,YANG Tao,NI Wei |
| (Clinical Laboratory, Jingzhou Traditional Chinese Medicine Hospital of Hubei Province, Jingzhou, Hubei 434000, China;Clinical Laboratory, Hubei Traditional Chinese Medicine Hospital, Wuhan, Hubei 430000, China) |
| Abstract: |
| Objective To study of serum anti-mullerian hormone (AMH), Interleukin-21 (IL-21) combined with sex hormones tests in prediction of premature ovarian failure (PDF) and its diagnosis value. Methods 168 patients with POF as the observation group from July 2014 to July 2016 in our hospital were nanalyzed by retrospective method. Alternatively, in the same period, 100 normal healthy women who has a normal menstrual cycle and basic endocrine were selected as a control group. The AMH and IL-21 were measured by radioimmunoassay, six hormones tests were measured by chemiluminescence. Results The level of AMH and estradiol E2 of PDF patients in the observation group reduced significantly, the difference has statistics significance (P<0.05), IL-21 increased significantly, the difference was statistically significant (P<0.05). The levels of follicle stimulating hormone and uteinizing hormone in observation group were significantly higher than the control group, the difference has statistics significance (P<0.05). Levels of progesterone and testosterone and prolactin were not statistically significant (P>0.05). Conclusion Anti-mullerian hormone gradually decline with age, it is a sensitive indicator of premature ovarian failure. The L-21 in PDF patients in observation group increased significnatly, it may be related to autoimmunity. They combined with sex hormone testing could improve the diagnosis value and prediction of the POF. |
| Key words: premature ovarian failure anti-mullerian hormone interleukin-21 sex hormones |
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