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宋祯彦,王珊珊,贺旭,龚盛强,刘晓丹,李平,成绍武.网络药理学方法研究石菖蒲治疗神经退行性疾病的作用机制[J].湖南中医药大学学报英文版,2017,37(8):848-855.[Click to copy
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| 网络药理学方法研究石菖蒲治疗神经退行性疾病的作用机制 |
| 宋祯彦,王珊珊,贺旭,龚盛强,刘晓丹,李平,成绍武 |
| (湖南中医药大学中西医结合心脑疾病防治湖南省重点实验室, 湖南 长沙 410208) |
| 摘要: |
| 目的 从系统水平研究石菖蒲治疗神经退行性疾病的有效成分和作用机制。方法 采用计算机网络药理学方法，从中药系统药理学数据库中筛选石菖蒲治疗神经退行性疾病的活性成分，并构建药物-靶标-疾病网络。结果 通过网络药理学方法筛选出石菖蒲活性成分20种，显示该中药化学成分和作用靶点与阿尔茨海默病、抑郁症和帕金森综合征等神经退行性疾病之间存在一定的联系。结论 通过网络药理学方法构建的石菖蒲网络可以将该中药化学成分的聚类、差异以及有效成分与相关靶标及疾病的复杂分子作用机制可视化。 |
| 关键词: 石菖蒲 神经退行性疾病 分子机制 网络药理学 |
| DOI：10.3969/j.issn.1674-070X.2017.08.009 |
| Received:March 16, 2017 |
| 基金项目:湖南省教育厅创新平台开放基金项目（15K088）；湖南省教育厅基金项目（14C0859）；湖南中医药大学创新团队项目；湖南省高校科技创新团队科研项目（15CXTD07）。 |
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| Study the Mechanism of Acorus tatarinowii on Neurodegenerative Diseases by Network Pharmacology |
| SONG Zhenyan,WANG Shanshan,HE Xu,GONG Shengqiang,LIU Xiaodan,LI Ping,CHENG Shaowu |
| (Key Laboratory of Hunan Province for Integrated Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To explore the mechanism of the active components of Acorus tatarinowii on neurodegenerative diseases by using network pharmacology at the system level. Methods The active ingredients of Acorus tatarinowii on neurodegenerative diseases were screened from TCM systems pharmacology database by network pharmacology method, and the drugs-targets-disease network was built. Results 20 active ingredients from Acorus tatarinowii were selected through the network pharmacology method. The results showed that those chemical compositions and related targets are correlated with the neurodegenerative diseases, such as Alzheimer's disease, depression and Parkinson syndrome and so on. Conclusion The construction of Acorus tatarinowii network by the network pharmacology could visually trace out the cluster and diversity of compounds, and explore the complex molecular mechanism of Acorus tatarinowii in neurodegenerative diseases. |
| Key words: Acorus tatarinowii neurodegenerative diseases molecular mechanism network pharmacology |
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