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李兴梅,王燕妮,郝尧.酸甘养阴，软坚散结方治甲亢的临床疗效及其肝保护作用观察[J].湖南中医药大学学报英文版,2017,37(5):540-543.[Click to copy
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| 酸甘养阴，软坚散结方治甲亢的临床疗效及其肝保护作用观察 |
| 李兴梅,王燕妮,郝尧 |
| (榆林市第二医院内分泌科, 陕西 榆林 719000) |
| 摘要: |
| 目的 探讨酸甘养阴、软坚散结方结合常规治疗甲状腺功能亢进症的临床疗效及其对肝的保护作用。方法 对108例确诊患有甲亢合并肝损伤的患者，随机分为他巴唑治疗的对照组与他巴唑加中药汤剂治疗的治疗组，每组各54例。治疗观察两个疗程，每个疗程30 d，观察患者症状改善情况，记录甲状腺激素水平、体质量及肝功能指标治疗前后的变化。结果 治疗组与对照组治疗后总有效率分别为94.4%、85.2%，两组间差异有统计学意义（P<0.05）；治疗后两组患者甲状腺激素指标水平优于治疗前，体质量增加（P<0.05），肝功能实验室指标优于治疗前（P<0.05）；治疗后两组患者甲状腺激素水平（FT3、FT4、TSH）及肝功能（ALT、AST、ALP、TbiL）组间差异具有统计学意义（P<0.05）。结论 酸甘化阴，软坚散结方能有效调节甲状腺功能，改善甲亢症状，保护肝功能，与西药他巴唑联合治疗甲亢疗效显著，具有重要临床意义。 |
| 关键词: 甲亢 肝损伤 酸甘养阴 软坚散结 他巴唑 |
| DOI：10.3969/j.issn.1674-070X.2017.05.021 |
| Received:July 27, 2016 |
| 基金项目:延安市科学技术研究发展计划项目（2015-0602）。 |
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| Effect of Suanganhuayin Ruanjiansanjie Formula in Treatment of Hyperthyroidism and its Hepatoprotective Activity |
| LI Xingmei,WANG Yanni,HAO Yao |
| (Department of Endocrinology, Yulin Second Hospital, Yulin, Shanxi 719000, China) |
| Abstract: |
| Objective To observe Suanganyangyin Ruanjiansanjie formula combined with convetinal therapy in treament of hyperthyroidism, and its hepatoprotective activity. Methods The 108 patients with hyperthyroidism combined with liver injury were randomly divided into the control group (administrated with methimazole for two courses) and treatment group (administrated with methimazole and TCM decoction for two courses), 54 cases in each group, one course was for 30 d. Level of thyroid function, body weight, liver function were tested before and after treatment. Results The total effective rates of treatment group and control group were 94.4% and 83.3%, respectively, there was statistical difference between two groups (P<0.05). The thyroid hormone level and body weight after treatment were higher than that berore treatment (P<0.05). The liver function indicators after treatment were significantly better than those after treatment (P<0.05).After treatment, thyroid hormones levels (FT3, FT4, TSH) and liver function indicators (ALT, AST, ALP, TbiL4) were statistically significant (P<0.05), and treament group was more efficient in indicator than control group (P<0.05). Conclusion Suanganhuayin Ruanjiansanjie formula combined with methimazole could significantly regulate the thyroid funtion, improve the symptoms and recovery liver functions, which has important clinical significance. |
| Key words: hyperthyroidism liver damage sour and sweet herbs to nourish Yin resolving hard lump methimazole |
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