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陈晓东,潘华峰,蔡甜甜,赵自明,赵金媛,林钟宇.亚硝基胍复制胃癌癌前病变大鼠模型的研究概况[J].湖南中医药大学学报英文版,2017,37(4):457-460.[Click to copy
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| 亚硝基胍复制胃癌癌前病变大鼠模型的研究概况 |
| 陈晓东,潘华峰,蔡甜甜,赵自明,赵金媛,林钟宇 |
| (广州中医药大学脾胃研究所, 广东 广州 510006;广东省中医药工程技术研究院, 广东 广州 510006;广州中医药大学经济管理学院, 广东 广州 510006) |
| 摘要: |
| N-甲基-N'-硝基-N-亚硝基胍（N-methyl-N'-nitro-N-nitrosoguanidine，MNNG）是一种化学诱变剂及致癌剂，人类在长期摄入MNNG后易致慢性萎缩性胃炎甚至胃癌，许多学者将MNNG作为诱发胃癌癌前病变（precancerous lesions of gastric cancer，PLGC）动物模型造模制剂，以制备出符合实验要求的PLGC动物模型。本文通过搜索近年来使用MNNG复制PLGC动物模型的相关研究，根据使用MNNG造模过程中所涉及到的造模方式分类，比较构建PLGC大鼠模型的多种方法，探寻更为简单易行的PLGC动物模型造模方式，为深入开展该病的相关研究提供更符合科研与临床实际要求的模型支撑。 |
| 关键词: N-甲基-N'-硝基-N-亚硝基胍 胃癌癌前病变 大鼠模型 造模方式 |
| DOI：10.3969/j.issn.1674-070X.2017.04.031 |
| Received:November 21, 2016 |
| 基金项目:国家自然科学基金（81473620、81673946）；广州市哲学社会科学发展“十三五”规划2016年度课题（2016GZJ07）；四川医事卫生法治研究中心2016年度项目（YF16-Q17）；广州市公共卫生服务体系建设研究基地2016年度课题；广州市社科联羊城青年课题（16QNXR16）；四川医事卫生法治研究中心2016年度项目（YF15-Y09） |
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| Research Status of MNNG in Building PLGC Model Rats |
| CHEN Xiaodong,PAN Huafeng,CAI Tiantian,ZHAO Ziming,ZHAO Jinyuan,LIN Zhongyu |
| (Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China;Research Institute of Chinese Medicine Engineering and Technology in Guangdong Province, Guangzhou, Guangdong 510006, China;School of Economics and Management, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China) |
| Abstract: |
| N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) is a kind of chemical mutagen and carcinogenic agents. Long-term intake of MNNG easily cause the occurrence of chronic atrophic gastritis and gastric cancer of humans. Many scholars regard MNNG as the preparation of making precancerous lesions of gastric cancer (PLGC) animal model which fit in with experimental requiments. In this paper, we searched about the studies that using MNNG to make PLGC animal model in recent years. The methods of building PLGC animal models were compared to seeking the more simple and high success rate way, which provide more meet the requirements of the scientific research and clinical practice model for in-depth development of the related research of this disease. |
| Key words: N-methyl-N'-nitro-N-nitrosoguanidine precancerous lesions of gastric cancer rat model building model method |
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