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邹龙,陈叶童,张依人,张可人,蒋龙波,孔思圻,彭买姣.疡必愈止痛片中木香挥发油的提取及包合工艺优化[J].湖南中医药大学学报英文版,2017,37(4):378-381.[Click to copy
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| 疡必愈止痛片中木香挥发油的提取及包合工艺优化 |
| 邹龙,陈叶童,张依人,张可人,蒋龙波,孔思圻,彭买姣 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 目的 优选疡必愈止痛片中木香挥发油的提取工艺及β-环糊精（β-CD）包合物的制备工艺。方法 以木香提油量为指标，用正交设计方法优选出木香挥发油的提取工艺；以挥发油包合率、包合物收得率、油转移率为指标，比较饱和水溶液法与研磨法；采用Box-Behnken设计-响应面法对研磨法包合工艺条件进行优化。结果 木香挥发油的最佳提取工艺为粉碎过60目筛，加4倍量水，提取6h；研磨法优于饱和水溶液法，最佳包合工艺条件为β-CD（g）与挥发油（1 mL）投料比为10：1，加水量3.6倍，研磨时间1h。结论 优选的提取和包合工艺操作方便、合理稳定，具有可行性。 |
| 关键词: 木香挥发油 疡必愈止痛片 正交设计 Box-Behnken设计 β-环糊精包合物 |
| DOI：10.3969/j.issn.1674-070X.2017.04.008 |
| Received:September 02, 2016 |
| 基金项目:校院“产学研”合作项目（20150029）；湖南中医药大学2015中药技能大学生创新实验（201503） |
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| The Extraction and β-Cyclodextrin Inclusion Process Optimization of Essential Oil from Radix Aucklandiae in Yangbiyu-Zhitong Tablets |
| ZOU Long,CHEN Yetong,ZHANG Yiren,ZHANG Keren,JIANG Longbo,KONG Siqi,PENG Maijiao |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To optimize the extraction process and β-cyclodextrin inclusion process of essential oil from of Radix Aucklandiae in Yangbiyu-Zhitong Tablets. Methods The Radix Aucklandiae oil extraction quantity as an index, the extraction process was optimized by using orthogonal design method. The saturated water solution method and grinding method were compared with volatile oil inclusion rate, the yield of inclusion and oil transfer rate as indexes. The inclusion process conditions of grinding method were optimized by Box-Behnken design-response surface method. Results The best extraction technology of Radix Aucklandiae is screened through mesh size of 60, with 4 times of water, extracting for 6 h. The grinding method is better than that of saturated water solution method, the best closure process conditions is β-CD (g) and the essential oil weight ratio of 10:1, 3.6 times of water, grinding time 1 h. Conclusion The optimized extraction and inclusion process is easy to operate, stable and feasible. |
| Key words: essential oil of Radix Aucklandiae Yangbiyu-Zhitong tablets orthogonal design Box-Behnken design β-cyclodextrin inclusion |
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