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邹柯涵,徐敏,罗书笛,邹国英,任碧琼.CK、Ki67、Gly-3及P53在肝细胞癌组织中的表达[J].湖南中医药大学学报英文版,2017,37(3):326-328.[Click to copy
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| CK、Ki67、Gly-3及P53在肝细胞癌组织中的表达 |
| 邹柯涵,徐敏,罗书笛,邹国英,任碧琼 |
| (湖南省妇幼保健院病理科, 湖南 长沙 410008;湖南省第二人民医院病理科、检验科, 湖南 长沙 410007) |
| 摘要: |
| 目的 探讨细胞角蛋白（CK）、核抗原（Ki67）、磷脂酰肌醇蛋白聚糖3（Gly-3）及抑癌基因P53在肝细胞癌（HCC）组织中的表达。方法 收集16例肝细胞肝癌患者癌组织及癌旁组织，采用免疫组化染色技术，分别检测CK、Ki67、Gly-3及P53，分析其表达情况。结果 免疫组化检测16例HCC癌组织中CK7、CK8/18、CK19的阳性率分别为50%（8/16）、93.8%（15/16）以及62.5%（10/16），Ki67的阳性率为75%（12/16），Gly-3阳性率为87.5%（14/16），P53的阳性率为50%（8/16）。结论 HCC患者癌组织中CK、Ki67、Gly-3及P53的表达有不同程度的上调，其中以CK8/18阳性率最高，Gly-3及Ki67次之，P53及CK7相对较低。 |
| 关键词: 肝细胞癌 免疫组化 细胞角蛋白 Ki67 Gly-3 P53 |
| DOI：10.3969/j.issn.1674-070X.2017.03.025 |
| Received:December 09, 2016 |
| 基金项目: |
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| Expression of CK, Ki67, Gly-3 and P53 in Hepatocellular Carcinoma Tissues |
| ZOU Kehan,XU Min,LUO Shudi,ZOU Guoying,REN Biqiong |
| (Department of Pathology, Maternal and Child Health Hospital of Hunan Province, Changsha, Hunan 410008, China;Department of Pathology and Clinical Laboratory, the Second People's Hospital of Hunan Province, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To investigate the expression of cytokeratin (CK), nuclear antigen (Ki67), Gly-3 and P53 in hepatocellular carcinoma (HCC). Methods CK, Ki67, Gly-3 and P53 were detected by immunohistochemical staining technique in 16 patients with hepatocellular carcinoma (HCC) respectively. Results The positive rates of cytokeratin 7, cytokeratin 8/18 andcytokeratin 19 in HCC tissues were 50% (8/16), 93.8% (15/16) and 62.5% (10/16), respectively. The positive rate of Ki67, Gly-3 and P53 were 75% (12/16), 87.5% (12/16), and 50% (8/16), respectively. Conclusion The expression of CK, Ki67, Gly-3 and P53 were up-regulated in HCC patients, with the highest positive rate of CK8/18, followed by Gly-3 and Ki67. The expression of P53 and CK7 were relatively low in HCC patients. |
| Key words: hepatocellular carcinoma immunohistochemistry CK Ki67 Gly-3 P53 |
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