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张国建.补肾化瘀方对老年性骨质疏松症肾虚血瘀证证候积分及预后的改善作用[J].湖南中医药大学学报英文版,2017,37(2):200-203.[Click to copy
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| 补肾化瘀方对老年性骨质疏松症肾虚血瘀证证候积分及预后的改善作用 |
| 张国建 |
| (北京市平谷区中医医院风湿科, 北京 101200) |
| 摘要: |
| 目的 探讨补肾化瘀方对老年性骨质疏松症肾虚血瘀证证候积分及预后的改善作用。方法 以2014年3月至2016年3月我院风湿病科收治的84例老年性骨质疏松症患者为研究对象，随机数字表法均分为2组各42例，对照组给予阿法骨化醇软胶囊及强骨胶囊治疗，观察组另给予补肾化瘀方治疗，观察治疗后2组临床疗效、血液生化指标[血清碱性磷酸酶（ALP）、L2-L4骨密度（BMD）、血钙（Ca2+）]、肾虚血瘀证证候积分、预后效果[膝关节功能（HSS）评分]及药物安全性。结果 治疗后观察组总有效率88.10%较对照组64.29%具有统计学意义（P<0.05）；治疗后2组ALP、肾虚血瘀证证候积分较治疗前显著降低，BMD、Ca2+、HSS评分显著升高，且治疗后观察组ALP、肾虚血瘀证证候积分较对照组降低显著，BMD、Ca2+、HSS评分升高显著，具有统计学意义（P<0.05）。结论 补肾化瘀方对老年性骨质疏松症患者临床疗效显著，是一种疗效确切、预后效果佳安全性高的中药组方，有较广泛的推广应用价值。 |
| 关键词: 老年性骨质疏松症 补肾化瘀方 肾虚血瘀 预后 |
| DOI：10.3969/j.issn.1674-070X.2017.02.023 |
| Received:February 15, 2016 |
| 基金项目:北京市医药卫生科技项目资助（20141A011105）。 |
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| Effects of Bushen Huayu Decoction in Improving Syndrome Scores and Prognosis of Kidney Deficiency and Blood Stasis Type of Senile Osteoporosis |
| ZHANG Guojian |
| (Department of Rheumatism, TCM Hospital of Pinggu District, Beijing 101200, China) |
| Abstract: |
| Objective To investigate the effects of Bushen Huayu decoction in improving syndrome scores and prognosis of kidney deficiency and blood stasis type of senile osteoporosis. Methods From march 2014 to march 2016, 84 cases with senile osteoporosis in our hospital were selected as study subjects and were randomly divided into two groups, 42 cases in each group. The control group was treated with alfacalcidol soft capsules and qianggu capsules, while the observation group was additionally treated with Bushen Huayu decoction. the clinical efficacy, blood biochemical parameters[serum alkaline phosphatase (alp), l2-l4 bone mineral density (bmd), serum calcium (ca2+)], scores of kidney deficiency and blood stasis, prognosis[knee function score (hss)] and drug safety were observed. Results After treatment, the total effective rate of the observation group was higher than that of the control group (88.10% vs 64.29%) (P<0.05). After treatment, ALP and scores of kidney deficiency and blood stasis were significantly lower than those before treatment, while BMD, ca2+ and HSS scores were significantly higher. the ALP and syndrome of kidney deficiency and blood stasis in the observation group were greater than those in control group (P<0.05). Conclusion Bushen Huayu decoction shows significant effect in the treatment of senile osteoporosis. the curative effect of Chinese medicine is exact and safe, it is with high application value. |
| Key words: senile osteoporosis Bushen Huayu decoction kidney deficiency and blood stasis prognosis |
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