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陈海交,林亚平,杨建文,张程程,刘薇薇,刘丽,刘密,彭艳.电针对糖尿病胃轻瘫大鼠胃排空率及胃电图的影响[J].湖南中医药大学学报英文版,2016,36(12):63-67.[Click to copy
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| 电针对糖尿病胃轻瘫大鼠胃排空率及胃电图的影响 |
| 陈海交,林亚平,杨建文,张程程,刘薇薇,刘丽,刘密,彭艳 |
| (湖南中医药大学研究生院, 湖南 长沙 410208;湖南中医药大学针灸推拿学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察电针对糖尿病胃轻瘫（diabetic gastroparesis，DGP）大鼠胃排空率及胃电图的影响。方法 将实验大鼠随机分为空白组、模型组、电针穴位组、电针非穴组、胃复安组，每组10只。DGP模型制备采用单次腹腔注射2%链脲佐菌素溶液和高糖高脂饮食喂养8周的方法。电针穴位组取大鼠“足三里”“梁门”“三阴交”穴，电针非穴组取穴位对照点，胃复安组予1.7%胃复安药液（1 mL/100 g）灌胃。用血糖仪测血糖；以酚红为标记物，检测大鼠胃排空率及小肠推进率；BL-420F生物机能系统记录大鼠胃电图。结果 与空白组比较，模型组、电针穴位组、电针非穴组和胃复安组大鼠症状积分、血糖均显著升高（P<0.01），模型组胃排空率显著降低（P<0.01），模型组、电针穴位组、电针非穴组和胃复安组小肠推进率显著降低（P<0.01），模型组、电针非穴组胃电图平均振幅显著降低（P<0.01）；与模型组比较，电针穴位组症状积分、血糖显著下降（P < 0.01，P < 0.05），胃排空率、小肠推进率明显增加（P < 0.05，P < 0.01），胃电图平均振幅明显增高（P<0.05）；与电针非穴组比较，电针穴位组症状积分明显下降（P<0.05）；与胃复安组比较，电针穴位组症状积分显著下降（P<0.01）。结论 电针可改善DGP模型大鼠一般状况，控制血糖水平，促进胃排空，改善胃运动障碍，调节胃电图平均振幅。 |
| 关键词: 糖尿病胃轻瘫 电针 胃排空率 小肠推进率 胃电图 |
| DOI：10.3969/j.issn.1674-070X.2016.12.017 |
| Received:July 03, 2016 |
| 基金项目:国家自然科学基金项目（81403487）；湖南省教育厅青年基金项目（14B128）。 |
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| Effects of Electroacupuncture on Gastric Emptying and Gastric Electrical in Rats with Diabetic Gastroparesis |
| CHEN Haijiao,LIN Yaping,YANG Jianwen,ZHANG Chengcheng,LIU Weiwei,LIU Li,LIU Mi,PENG Yan |
| (Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Acupuncture and Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe the effects of electroacupuncture (EA) on gastric emptying and gastric electrical in diabetic gastroparesis (DGP) rats. Methods Rats were randomly divided into the blank group, model group, EA acupoint group, EA non-acupoint, metoclopramide group, ten rats in each group. The DGP model was established by a single-dose intraperitoneal injected of 2% streptozotocin and raised by high-sugar and high-fat fodder irregularly for 8 weeks. EA group was applied to "Zusanli", "Liangmen" and "Sanyinjiao", and EA non-acupoints group was given control point. Those rats of the medication group were given with 1.7% metoclopramide (1 mL/100 g). The blood sugar level was measured by glucometer, the effects on gastric emptying were measured after intragastric application of phenol red. Electrogastrogram (EGG) was recorded with BL-420F biological function system. Results Compared with the blank group, symptoms integral and blood sugar level of rats in the model group, EA acupoint group, EA non-acupoint group and metoclopramide group were significantly higher than those in normal control group (P<0.01). The gastric emptying in the model group were significantly decreased (P<0.01). The small intestinal propulsion rates in the model group, EA acupoint group, EA non-acupoint group and metoclopramide group were significantly higher than those in normal control group (P<0.01). The average amplitude of gastric electricity in the model group and EAnon-acupoint group were significantly decreased (P<0.01). Compared with the model group, symptoms integral and blood sugar level of rats in the EA acupoint group were significantly lower than those in model group (P < 0.01, P < 0.05). The gastric emptying rates and small intestinal propulsion rates in the EA acupiont group were significantly increased (P < 0.05, P < 0.01). The average amplitude of electrogastrogram in the EA acupiont group were significantly increased (P<0.05). Compared with the EA non-acupoint group, symptoms integral of rats in the EA acupoint group were significantly lower than those in EA non-acupoint group (P<0.05). Compared with the metoclopramide group, symptoms integral of rats in the EA acupoint group were significantly lower than those in metoclopramide group (P<0.01). Conclusion EA can improve the general situation of DGP rats, regulate blood sugar levels, promote gastric emptying, improve gastric movement disorders and regulate the average amplitude of gastric electricity. |
| Key words: diabetic gastroparesis electroacupuncture gastric emptying propulsion rate of small intestine electrogastrogram |
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