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李建超,彭俊,曾志成,姚小磊,徐剑,彭抿,江冰,谭涵宇,彭清华.原发性开角型青光眼患者眼血流动力学的改变及与中医证型关系的研究[J].湖南中医药大学学报英文版,2016,36(12):27-30.[Click to copy
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| 原发性开角型青光眼患者眼血流动力学的改变及与中医证型关系的研究 |
| 李建超,彭俊,曾志成,姚小磊,徐剑,彭抿,江冰,谭涵宇,彭清华 |
| (湖南省郴州市第一人民医院眼科, 郴州 420000;湖南中医药大学第一附属医院, 长沙 410007;湖南省桂阳县人民医院眼科, 郴州 430000;湖南省长沙星沙人民医院眼科, 长沙 410600;中南大学湘雅二医院眼科, 长沙 410006) |
| 摘要: |
| 目的 探讨原发性开角型青光眼患者眼血流动力学的改变及其与中医辨证分型之间的关系。方法 采用彩色超声多普勒成像（CDI）对102例原发性开角型青光眼患者眼血流动力学的改变进行了检测。结果 开角型青光眼及其中医证型（分为肝郁气滞证、痰湿犯目证、肝肾阴虚证）在眼动脉（OA）血流参数中，与正常组相比，PSV、EDV、AV差异均有统计学意义（P < 0.05或P < 0.01）；在视网膜中央动脉（CRA）血流参数中，与正常组相比，PSV、EDV和AV差异均有统计学意义（P < 0.05或P < 0.01），其变异程度依次为肝郁气滞证组 > 痰湿犯目证组 > 肝肾阴虚证组。结论 原发性开角型青光眼患者OA和CRA的血流速度下降明显，血流阻力增加，眼局部血液循环障碍，OA和CRA的血流参数可作为反映开角型青光眼及其中医证型间局部血瘀程度的一项重要指标。 |
| 关键词: 青光眼 开角型 眼血流动力学 辨证分型 肝郁气滞证 痰湿犯目证 肝肾阴虚证 |
| DOI：10.3969/j.issn.1674-070X.2016.12.007 |
| Received:August 01, 2016 |
| 基金项目:国家自然科学基金资助项目（81273807，81403437）；教育部博士学科点基金资助项目（20124323110006）；湖南省自然科学基金重点资助项目（11JJ2050）；湖南省教育厅科研基金重点资助项目（06A052，10A094）；湖南省研究生创新基金重点资助项目（CX2013A013）；中医诊断学国家重点学科开放基金重点项目（2014-06）；湖南省高层次卫生人才“225”工程培养项目资助；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 |
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| Study on the Relationship between the Changes of Ocular Hemodynamics in Patients with Primary Open Angle Glaucoma and the TCM Syndrome Types |
| LI Jianchao,PENG Jun,ZENG Zhicheng,YAO Xiaolei,XU Jian,PENG Min,JIANG Bing,TAN Hanyu,PENG Qinghua |
| (Chenzhou First People's Hospital of Hunan, Chenzhou, Hunan 420000, China;The First Affliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Guiyang People's Hospital of Hunan, Chenzhou, Hunan 430000, China;Xingsha People's Hospital of Hunan, Changsha, Hunan 410600, China;Xiangya Second Hospital of Central South University, Changsha, Hunan 410006, China) |
| Abstract: |
| Objective To explore the relationship between the changes of ocular hemodynamics in patients with primary open angle glaucoma and the TCM Syndrome Types. Methods The changes of ocular hemodynamics from 102 cases of primary open-angle glaucoma patients were detected by using color doppler imaging (CDI). Results Compared with the normal group, PSV, EDV, AV in flow parameters of ophthalmic artery (OA) in the patients with open angle glaucoma and TCM syndrome types (liver depression and Qi stagnation syndrome, phlegm-damp invading the eyes syndrome, liver-kidney Yin deficiency syndrome) were statistically significant (P < 0.05 or P < 0.01). In the blood flow parameters of central retinal artery (CRA), PSV, EDV, AV were also satistically significant (P < 0.05 or P < 0.01), the degrees of variation were, in order, liver constraint and Qi stagnation group > phlegm-damp invading the eyes group > liver-kidney Yin deficiency group. Conclusion The blood flow rate of OA and CRA in patients with primary open angle glaucoma decreased significantly, blood flow resistance increased, and with ocular local blood circulation disorders. The blood flow parameters of OA and CRA can be used as an important index to reflect the degree of local blood stasis between the open angle glaucoma and TCM syndrome types. |
| Key words: glaucoma open angle type ocular hemodynamics syndrome differentiation type liver depression and Qi stagnation syndrome phlegm-damp invading the eyes syndrome liver-kidney Yin deficiency syndrome |
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