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何宜荣,赵国荣,肖碧跃,何栋,贺又舜,艾碧琛.凉膈散、银翘散对早期脓毒症炎症因子干预作用比较研究[J].湖南中医药大学学报英文版,2016,36(12):7-10.[Click to copy
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| 凉膈散、银翘散对早期脓毒症炎症因子干预作用比较研究 |
| 何宜荣,赵国荣,肖碧跃,何栋,贺又舜,艾碧琛 |
| (湖南中医药大学中医学院, 湖南 长沙 410208;湖南中医药大学中医学院, 湖南 长沙 410208;湖南中医药大学研究生院, 湖南 长沙 410208) |
| 摘要: |
| 目的 观察凉膈散、银翘散对早期脓毒症炎症因子IL-1β、TNF-α、IL-10的不同干预作用。方法 将40只新西兰大耳白兔随机分成空白对照组、模型组、银翘散治疗组、凉膈散治疗组、地塞米松对照组，采用耳缘静脉注射大肠杆菌内毒素的方法建立脓毒症模型，造模0.5 h后药物干预，4 h后观察兔一般情况及体温，检测血浆内毒素、促炎因子IL-1β、TNF-α及抗炎因子IL-10水平。结果 银翘散组兔全身情况好转，体温、血浆内毒素、IL-1β、TNF-α的水平均比模型组降低（P<0.01 or 0.05）；凉膈散组兔全身症状加重，体温、血浆内毒素、IL-1β、TNF-α、IL-10与模型组差异无统计学意义（P>0.05）。结论 银翘散能抑制早期脓毒症卫分证相关阶段促炎因子IL-1β、TNF-α的释放而减轻炎症反应、改善症状，但凉膈散不能抑制IL-1β、TNF-α释放、减轻炎症反应。 |
| 关键词: 银翘散 凉膈散 脓毒症 卫分证 炎症因子 |
| DOI：10.3969/j.issn.1674-070X.2016.12.002 |
| Received:June 21, 2016 |
| 基金项目:国家自然科学基金项目（30801473，81603535），湖南省自然科学基金项目（14JJ3119），湖南中医药大学“中医经典理论与经方应用研究”科技创新团队项目，湖南中医药大学中医临床基础重点学科。 |
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| Comparisons of the Effects of Liangge Powder and Yinqiao Powder on Inflammatory Cytokines in Early Stage of Sepsis |
| HE Yirong,ZHAO Guorong,XIAO Biyue,HE Dong,HE Youshun,AI Bichen |
| (College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To observe different effects of Liangge Powder and Yinqiao Powder on inflammatory cytokines IL-1β, TNF-α and IL-10 in early stage of sepsis. Methods 40 rabbits were randomly divided into blank control group, model group, Yinqiao Powder therapy group, Liangge Powder therapy group and dexamethasone control group. The sepsis model was established by injecting LPS into rabbits' ear vein, which was given drug intervention after 0.5 h of modeling. After 4 h of modeling, the general conditions, temperatures, levels of plasma endotoxin, IL-1β, TNF-α and IL-10 were observed. Results Symtoms in Yinqiao Powder therapy groups were relieved, and their temperatures, levels of plasma endotoxin, IL-1β and TNF-α decreased compared with model group (P < 0.01 or P < 0.05). Symptoms in Liangge Powder therapy group turned into more serious, levels of plasma endotoxin, IL-1β, TNF-α and IL-10 had no significant difference compared to model group (P>0.05). Conclusion Yinqiao Powder can inhibit the releases of pro-inflammatory cytokines of IL-1β and TNF-α in Weifen syndrome related phase of early stage of sepsis, and it can reduce the inflammatory reaction and relieve the symptoms, while Liangge Powder can not. |
| Key words: Yinqiao Powder Liangge Powder sepsis Weifen syndrome inflammatory cytokines |
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