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徐剑,彭俊,姚小磊,喻娟,龙达,李建超,曾志成,彭抿,彭清华.原发性开角型青光眼患者血管内皮、血小板功能改变及与中医证型关系的研究[J].湖南中医药大学学报英文版,2016,36(11):37-40.[Click to copy
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| 原发性开角型青光眼患者血管内皮、血小板功能改变及与中医证型关系的研究 |
| 徐剑,彭俊,姚小磊,喻娟,龙达,李建超,曾志成,彭抿,彭清华 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;广西中医药大学附属瑞康医院, 广西 南宁 330000;湖南省郴州市第一人民医院眼科, 湖南 郴州 420000;湖南省桂阳县人民医院眼科, 湖南 郴州 430000;湖南省长沙星沙人民医院眼科, 湖南 长沙 410600) |
| 摘要: |
| 目的 探讨原发性开角型青光眼的发病机制。方法 将85例原发性开角型青光眼患者分为高眼压型组、正常眼压型组，并与24例正常人进行对照，对其血管内皮和血小板功能指标的改变及与中医辨证分型的关系进行了研究。结果 原发性开角型青光眼高眼压型患者和正常眼压型青光眼患者与正常组相比，内皮素（ET）、血浆血栓素B2（TXB2）、血浆β-血栓球蛋白（β-TG）、vonWillebrand因子（vWF）、6-酮-前列环素F1α（6-keto-PGF1α）、T/K比值均有显著性差异（P<0.05或P<0.01）。原发性开角型青光眼中医辨证分型各组与正常组比较，均表现为ET-1、TXB2、β-TG、vWF和T/K比值升高，6-keto-PGF1α下降。其中肝郁气滞证和肝肾亏虚证组分别与正常组相比，TXB2、β-TG、vWF、6-keto-PGF1α和T/K比值均有显著性差异（P<0.05或P<0.01）；痰湿泛目证组与正常组相比，T/K比值有显著性差异（P<0.05）。结论 原发性开角型青光眼高眼压型患者和正常眼压型青光眼患者均存在明显的血管内皮细胞受损和血小板聚集性增强，血液呈现高凝状态的血瘀病理改变，而正常对照组的血瘀改变不明显。在中医证型中，这种血瘀病理以肝郁气滞证最明显，肝肾亏虚证次之，痰湿泛目证最轻，呈现肝郁气滞证 >肝肾亏虚证 >痰湿泛目证的趋势。 |
| 关键词: 原发性开角型青光眼 中医证型 血管内皮 血小板 |
| DOI：10.3969/j.issn.1674-070X.2016.11.010 |
| Received:August 01, 2016 |
| 基金项目:国家自然科学基金资助项目（81273807，81403437，81603665）；教育部博士学科点基金资助项目（20124323110006）；湖南省自然科学基金重点资助项目（11JJ2050）；湖南省教育厅科研基金重点资助项目（06A052，10A094）；湖南省研究生创新基金重点资助项目（CX2013A013）；中医诊断学国家重点学科开放基金重点项目（2014-06，2015ZYZD02）；湖南省高层次卫生人才“225”工程培养项目资助；国家中医药管理局中医眼科学重点学科建设项目；湖南省中医五官科学重点学科建设项目。 |
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| Changes in the Function of Vascular Endothelia and Blood Platelets and Its Relationship with TCM Syndromes in Primary Open-Angle Glaucoma Patients |
| XU Jian,PENG Jun,YAO Xiaolei,YU Juan,LONG Da,LI Jianchao,ZENG Zhicheng,PENG Min,PENG Qinghua |
| (The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, Guangxi 330000;Department of Ophthalmology, the First People's Hospital of Chenzhou, Chenzhou, Hunan 420000, China;Department of Ophthalmology, Guiyang County People's Hospital, Chenzhou, Hunan 430000, China;Department of Ophthalmology, Xingsha People's Hospital, Changsha, Hunan 410600, China) |
| Abstract: |
| Objective To investigate the pathogenesis of primary open-angle glaucoma. Methods The 85 patients with open-angle glaucoma were divided into 2 groups, including the high IOP group and the normal IOP group, and their data were compared with that of 24 normal persons. These data included the function changes of vascular endotelia and blood platelets and their relationship with TCM syndromes. Results Compared with the normal group, ET-1, TXB2, β-TG, vWF, 6-keto-PGF1α and T/K values in the high IOP group and the normal IOP group had significant difference (P<0.05 or P<0.01). ET-1, TXB2, β-TG, vWF and T/K values were higher and 6-keto-PGF1α was lower in all syndromes of open-angle glaucoma than those in normal group. Compared with the normal group, the TXB2, β-TG, vWF, 6-keto-PGF1α and T/K in sydrome of liver-Qi stagnation group and the deficiency of liver and kidney group were statistically significant (P<0.05 or P<0.01), T/K value had significant difference. Conclusion There are obvious injury of vascular endothelia cell, increased aggregation of the blood platelets, and the stagnation of the blood in the high IOP group and the normal IOP group, while the change of blood stagnation in normal control group is not distinct. For all the syndromes, the most obvious pathologic status of blood stasis occurs in the syndrome of liver-Qi stagnation, the second syndrome is the deficiency of liver and kidney, and the mildest is the group of eye phlegm flooding, the trend of the syndromes is liver-Qi stagnation > deficiency of liver and kidney > eye phlegm flooding. |
| Key words: primary open-angle glaucoma traditional Chinese medicine syndrome vascular endothelia blood platelet |
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