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张伟,赵俊杰,李涛,陈建宗.红景天苷对神经退行性疾病作用的研究进展[J].湖南中医药大学学报英文版,2016,36(7):86-90.[Click to copy
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| 红景天苷对神经退行性疾病作用的研究进展 |
| 张伟,赵俊杰,李涛,陈建宗 |
| (第四军医大学西京医院中医药研究中心, 陕西 西安 710032) |
| 摘要: |
| 红景天苷（Salidroside，Sal）是景天科植物红景天的主要活性成分之一。研究显示，Sal在帕金森病（Parkinson's disease，PD）、阿尔茨海默病（Alzheimer's disease，AD）和亨丁顿舞蹈症（Huntington's disease，HD）中的氧化和抗氧化系统起到双向调节作用。此外，Sal在PD和AD中可通过维持线粒体功能、减少ROS生成和增加抗凋亡蛋白和凋亡蛋白的比例以抑制细胞凋亡，进而促进神经元存活。但其在神经退行性疾病中的具体机制，如Sal通过哪种机制调控线粒体形态和功能的稳定以及Sal在疾病模型中的体内代谢分布改变等，仍有待进一步深入研究和临床验证。本文仅就Sal对神经退行性疾病的作用研究进展进行综述，为进一步研究提供参考。 |
| 关键词: 红景天苷 神经退行性疾病 帕金森氏病 阿尔茨海默病 亨丁顿舞蹈症 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2016.07.023 |
| Received:September 11, 2015 |
| 基金项目:国家自然科学基金项目（81173590）。 |
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| Progress on the Role of Salidroside in Neurodegenerative Diseases |
| ZHANG Wei,ZHAO Junjie,LI Tao,CHEN Jianzong |
| (Research Center of Traditional Chinese Medicine of Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China) |
| Abstract: |
| Salidroside (Sal) is one of the main active ingredients in Rhodiola belonging to Crassulaceae.Studies show that Sal plays a role in the regulation of both excitatory and inhibitory in the oxidation and antioxidant system in the Parkinson's disease (PD),Alzheimer's disease (AD) and Huntington's disease (HD).In addition,Sal can inhibit the apoptosis by maintaining the mitochondrial function,accelerating the reduction of ROS generation and increasing the proportion of anti apoptosis and apoptosis proteins,and then promote the survival of neurons in PD and AD.Therefore,it has broad potential application in the clinical treatment and prevention of neurodegenerative diseases.However,the specific mechanisms of Sal,such as what is the mechanism of stabling the mitochondrial morphology and function,and the changes of the metabolic distribution in the neurodegenerative disease model,which are still need to be further studied both in vitro and in vivo study.This paper reviews the role of salidroside in neurodegenerative diseases and provides reference for further study. |
| Key words: salidroside neurodegenerative diseases Parkinson's disease Alzheimer's disease Huntington's disease mechanism of action |
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