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刘应科,任昕昕,方琼杰,郑源,丁一芸,周义山,沐雪滢,王俊宏.静宁颗粒治疗56例小儿多动症气阴两虚证临床观察[J].湖南中医药大学学报英文版,2016,36(4):49-52.[Click to copy
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| 静宁颗粒治疗56例小儿多动症气阴两虚证临床观察 |
| 刘应科,任昕昕,方琼杰,郑源,丁一芸,周义山,沐雪滢,王俊宏 |
| (北京中医药大学东直门医院儿科, 北京 100700;北京中医药大学, 北京 100029;北京市和平里医院, 北京 100013) |
| 摘要: |
| 目的 探讨静宁颗粒经验方治疗小儿多动症气阴两虚证患儿的临床疗效及不良反应。方法 采用中医、西医相应诊断标准纳入于2013年9月到2015年10月期间就诊于北京中医药大学东直门医院儿科门诊、北京市和平里医院儿科门诊的注意力缺陷多动障碍患儿60例，服用静宁颗粒12周，采用前后自身对照，观察有效率、中医证候评分、多动指数、划销试验、注意力缺陷多动障碍量表（SNAP-IV）以及相关安全指标和记录不良反应。结果 60例患儿中，脱落4例，总共完成56例临床观察。痊愈2例，显效12例，有效36例，无效6例，总有效率85.71%。治疗前后中医证候总积分、中医主要证候总积分、划销测验中计分、漏划数具有显著统计学差异（P<0.01）；多动指数、注意缺陷多动障碍量表积分改善具有统计学差异（P<0.05）；划销测验中错划数不具统计学差异（P>0.01）。结论 静宁颗粒治疗小儿多动症气阴两虚型具有较好临床疗效和安全性。 |
| 关键词: 静宁颗粒 小儿多动症 气阴两虚证 太子参 熟地黄 枸杞子 |
| DOI：10.3969/j.issn.1674-070X.2016.04.013 |
| Received:December 03, 2015 |
| 基金项目:国家科技重大专项-重大新药创制（2014ZX09304306-002）。 |
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| Clinical Observation of Jingning Granule in the Treatment of 56 Cases of ADHD Children with Qi-Yin Deficiency Syndrome |
| LIU Yingke,REN Xinxin,FANG Qiongjie,ZHENG Yuan,DING Yiyun,ZHOU Yishan,MU Xueying,WANG Junhong |
| (The Pediatrics Department, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China;Beijing University of Chinese Medicine, Beijing 100029, China;Beijing Hepingli Hospital, Beijing 100013, China) |
| Abstract: |
| Objective To explore the clinical efficacy and adverse reactions of Jingning experienced granule in the treatment of children with ADHD of Qi and yin deficiency syndrome. Methods The traditional Chinese medicine and Western medicine diagnostic criterias were incorporated during September 2013 to October 2015, 60 cases of children with attention deficit hyperactivity disorder were admitted to the pediatric clinic of Beijing University of Chinese Medicine Dongzhimen Hospital and the pediatric clinic of Beijing Hepingli Hospital. After taking Jingning granule for 12 weeks, before and after self-control was used, and the efficiency, TCM syndrome score, hyperactivity index, draw pin test, the amount of attention deficit hyperactivity disorder table (IV) and the related safety index and adverse reactions were recorded using self-control. Results Among 60 cases, 4 cases were lossed, a total of 56 cases have completed the clinical observation, of which 2 cases were cured, 12 cases markedly effective, 36 cases effective, 6 cases ineffective, the total efficiency is of 85.71%. Before and after the treatment, there are significant difference (P<0.01) in TCM symptom total score, TCM main syndrome total score, score of Cancellation test and leakage strokes. The hyperactivity index and attention deficit hyperactivity disorder scale score were improvemented with significant difference (P<0.05). The wrongly classified number in designated cancellation test had no statistical difference (P>0.01). Conclusion Jingning Granule in the treatment of children with ADHD of Qi Yin deficiency shows better clinical efficacy and safety. |
| Key words: Jingning granule attention deficit hyperactivity disorder Qi-Yin deficiency radix pseudostellariae Radix Rehmanniae Preparata fructus lycii |
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