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钟周,周甲龙,葛小平,王民主,柳春旺,唐江萍,程小芸,胡志希.长沙市重性精神疾病社区药物治疗的安全性研究[J].湖南中医药大学学报英文版,2016,36(1):66-69.[Click to copy
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| 长沙市重性精神疾病社区药物治疗的安全性研究 |
| 钟周,周甲龙,葛小平,王民主,柳春旺,唐江萍,程小芸,胡志希 |
| (长沙市精神病医院, 湖南 长沙 410004;湖南中医药大学, 湖南 长沙 410007) |
| 摘要: |
| 目的 评价分析长沙重性精神疾病社区药物治疗的安全性。方法 以社区药物治疗的365例重性精神病患者为对象，对3次锥体外系副反应量表（rating scale for extratyramidal side effects，RSESE）、异常不自主运动量表（abnomal involuntary movement scale，AIMS）、精神性不良反应量表（udvalg for kliniske under-sogelser，UKU）及实验室、心电图检查统计分析以探讨药物治疗安全性。结果 3次RSESE评分值比较无统计学意义；第1、3次AIMS评分值比较有统计学意义（P<0.05）；第1次与第2、3次UKU评分值比较有统计学意义（P<0.05）；第1、3次血常规间、第1次与第2或3次血糖间、第1或2次与第3次血脂间、第1、2次肾功能间比较有统计学意义（P<0.05）；3次肝功能、激素、心电图比较无统计学意义。锥体外系副反应以震颤、肘强直、固定姿态多见；异常不自主运动副反应以上肢面部、唇口周部多见；精神性不良反应以无力、思睡、注意力下降多见。结论 重性精神疾病社区药物治疗不良反应评估稳定，安全性较高，对药物锥体外系副反应及生化、血象、心电图异常情况，须监测、复诊，以减少不良反应的发生。 |
| 关键词: 重性精神病患者 社区卫生服务 药物安全性 锥体外系副反应 异常不自主运动 精神性不良反应 |
| DOI：10.3969/j.issn.1674-070X.2016.01.017 |
| Received:October 12, 2015 |
| 基金项目:民生科技支撑资金专项（K1207050-31）。 |
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| Study of Drug Safety on Severe Mental Illness in Changsha Community |
| ZHONG Zhou,ZHOU Jialong,GE Xiaoping,WAN Minzhu,LIU Chunwang,TANG Jiangping,CHEN Xiaoyun,HU Zhixi |
| (Changsha Psychiatric Hospital, Changsha, Hunan 410208, China;Hunan University of Chinese Medicine, Changsha, Hunan 410007, China) |
| Abstract: |
| Objective To evaluate and analyze the medication safety of severe mental illness in Changsha community. Methods In community drug for the treatment of 365 cases of severe mental illness patients for object, through three times extrapyramidal (RSESE), abnormal involuntary movement (AIMS), adverse reactions (UKU) scale and laboratory examination, electrocardiogram(ECG) examination were carried on the statistical analysis to discuss treatment medication safety. Results Three RSESE score values have no statistical significance; The difference between the first and third times AIMS score was statistically significant (P<0.05); The first time UKU score compared the second and third time value was statistically significant (P<0.05); The blood routine examination between first and third time, blood glucose between first and second or third time, blood lipid between first or second with the third time, renal function between first and second time were statistical significance(P<0.05). Three times of liver function, hormone, ECG ratio have no statistical significance. The extrapyramidal adverse reactions were major with tremor, elbow stiffness, fixed posture; abnormal involuntary movement adverse reactions were major with upper facial, lip weeks; psychiatric adverse reactions were major with weakness, drowsiness, attention to fall. Conclusions Drug treatment for severe mental illness community was with stability for adverse reactions evaluation and high safety. We should regularly monitor and subsequent visit to drug extrapyramidal side effects, biochemical, blood picture, ECG abnormalities, in order to reduce the occurrence of adverse reactions. |
| Key words: severe mental patients community health service drug safety extrapyramidal system side reaction abnormal involuntary movement spiritual adverse effect |
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