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肖 瑶1，彭逢春2，王净净3*，刘春华4，左亚杰5，何 群3，何英樱3，袁斯思6.眩晕定颗粒对后循环缺血性眩晕家兔[J].湖南中医药大学学报英文版,2015,35(9):26-30.[Click to copy
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| 眩晕定颗粒对后循环缺血性眩晕家兔 |
| 肖瑶1，彭逢春2，王净净3*，刘春华4，左亚杰5，何群3，何英樱3，袁斯思6 |
| (1.湖南省人民医院，湖南 长沙 410005;2.湖南中医药高等专科学校附属第一医院，湖南 株洲 412000;3.湖南中医药大学，湖南 长沙 410208;4.湖南省中医药研究院附属医院，湖南 长沙 410006;5.湖南中医药大学第一附属医院，湖南 长沙 410007; 6.湖南郴州市中医院，湖南 郴州 423000) |
| 摘要: |
| 目的 探讨眩晕定颗粒对家兔气虚血瘀型后循环缺血性眩晕模型前庭神经核区Bax、Bcl-2及脑源性神经生长因子（BDNF）表达的影响。方法 建立气虚血瘀型后循环缺血性眩晕家兔模型，以西比灵为西药对照，眩晕宁为中药对照，免疫组化法测定前庭神经核区Bax、Bcl-2和BDNF表达。结果 造模后模型组家兔脑干前庭神经核Bcl-2及BDNF表达显著下降，Bax表达上调，差异有统计学意义（P＜0.05）；药物干预后，与模型组比较，眩晕定颗粒使家兔脑干前庭神经核Bcl-2及BDNF表达上调，并可抑制Bax的表达。结论 眩晕定颗粒治疗家兔实验性眩晕的作用与其促进脑组织Bcl-2、BDNF表达，抑制Bax表达有关。 |
| 关键词: 眩晕定颗粒 后循环缺血性眩晕 前庭神经核 B细胞淋巴瘤/白血病-2 Bcl相关X蛋白 脑源性神经生长因子 |
| DOI： |
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| 基金项目:长沙市科技局项目（K0905040-31）。 |
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| Effects of Xuanyunding Granules on the Bcl-2, Bax and BDNF in PCIV Model Rabbits |
| Yao Xiao1， Feng-Chun Peng2， Jing-Jing Wang3*， Chun-Hua Liu4， Ya-Jie Zuo5， Qun He，Ying-Ying He3, Si-Si Yuan6 |
| (1. Hunan People's Hospital, Changsha, Hunan 410005, China; 2. The First Affiliated Hospital of Hunan TCM College, Zhuzhou, Hunan 412000, China; 3. Hunan University of Chinese Medicine, Changsha, Hunan 410208, China; 4. Affiliated Hospital to Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China; 5. The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China; 6. Chenzhou Chinese Medicine Hospital, Chenzhou, Hunan 423000, China.) |
| Abstract: |
| Objective To investigate the effect of Xuanyunding Granules on the expression of Bax, Bcl-2 and BDNF in PCIV model rabbits with the syndrome of Qi deficiency and blood stasis (QDBS)． Methods The PCIV model rabbits with QDBS were prepared，Sibelium as the control of Western medicine and Xuanyunning as the control of Chinese medicine. The expression of Bax, Bcl-2 and BDNF was tested by immuohistochemisty. Results After the modeling, the contents of Bcl-2 and BDNF were lower obviously, and the expression of Bax was higher, the difference has statistical significance (P<0.05). After the medicine intervention, compared with model group, Xuanyunding Granules could improve the expression of Bcl-2 and BDNF, and reduced the Bax expression. Conclusion Xuanyunding Granules in the treatment of vertigo in rabbits is related with its promoting the expression of Bcl-2 and BDNF, and inhibiting the Bax expression. |
| Key words: Xuanyunding Granules posterior circulation ischemia vertigo vestibular nuclear Bcl-2 Bax BDNF |
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