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李旭.不同中医治法对慢性乙型肝炎病毒感染患者外周血IL-2 和IFN-γ 的影响[J].湖南中医药大学学报英文版,2012,32(7):61-63.[Click to copy
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| This paper
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| 不同中医治法对慢性乙型肝炎病毒感染患者外周血IL-2 和IFN-γ 的影响 |
| 李旭 |
| (湖南中医药大学第二附属医院) |
| 摘要: |
| 目的观察健脾法、补肾法、解毒法分别联合西药治疗对慢性乙型肝炎病毒（HBV）感染患者外周血细胞因
子白介素-2（IL-2）和干扰素-γ（IFN-γ）的影响。方法将120 例慢性HBV 感染患者随机分为对照组、健脾组、补肾组
和解毒组各30 例。对照组给予拉米夫定治疗，健脾组给予拉米夫定+四君子汤治疗，补肾组给予拉米夫定+六味地黄丸
治疗，解毒组给予拉米夫定+甘露消毒丹治疗。疗程1 年。观察各组治疗前和疗程结束后血清IL-2 和IFN-γ 水平。结
果治疗前各组血清IL-2 和IFN-γ 水平差异无统计学意义(P＞0.05)；治疗后各组患者血清IL-2、IFN-γ 水平均显著上
升(P<0.05)，其中健脾组、补肾组上升较对照组显著(P<0.05，P<0.01)，补肾组上升较健脾组显著(P<0.05)，解毒组与健脾
组比较差异无统计学意义(P＞0.05)。结论补肾法改善慢性HBV 感染患者细胞因子IL-2 和IFN-γ 失衡状态优于健脾
法和解毒法。 |
| 关键词: 慢性乙型肝炎病毒感染 白介素-2 干扰素-γ 健脾法 补肾法 解毒法 |
| DOI： |
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| 基金项目:无 |
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| Effects of different Traditional Chinese Medical treatmentson peripheral blood IL-2 and IFN-γ in patientswith chronic HBV infection |
| LI Xu |
| (Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine) |
| Abstract: |
| Objective To observe the effects of Traditional Chinese Medical remedy of
strengthening the spleen, tonifying the kidney and detoxification combined with Western Medicine
on peripheral blood cytokines IL-2 and IFN-γ in patients with chronic HBV infection. Methods
120 patients with chronic HBV infection were randomly divided into control group, strengthening
the spleen group， tonifying the kidney group and detoxification group, with 30 patients in
each group. The control group was treated with lamivudine. The strengthening the spleen group
was given lamivudine and Sijunzi decoction. The tonifying the kidney group was given lamivudine
and Liuwei Dihuang pills. The detoxification group was given lamivudine and Ganlu Xiaodu pills.
The treatment course was 1 year. The levels of serum IL-2 and IFN-γ were measured before and
after treatments. Results Before treatments, the differences of serum cytokine levels among 4 groups
were not statistically significant (P＞0.05). After treatment, the levels of serum IL-2 and IFN-γ increased
significantly in 4 groups (P<0.05). Compared with control group, the levels of serum IL-2and IFN-γ in strengthening the spleen group and tonifying the kidney group increased significantly
after treatments (P<0.05，P<0.01), and the changes were most obvious in tonifying the kidney group
(with statistic differences)(P<0.05). There was no significant difference between detoxification group
and strengthening the spleen group after treatments (P＞0.05). Conclusion The method of tonifying
the kidney is better than strengthening the spleen and detoxification methods to improve the imbalance
of cytokine IL-2 and IFN-γ in patients with chronic HBV infection. |
| Key words: Chronic HBV infection IL-2 IFN-γ the method of strengthening the spleen the method of tonifying the kidney the method of detoxification |
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