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郭漩、弭艳红、王小娟 、谭华梁、郭建生、徐寅、张鑫、饶文娟、李永静、郭蕾蕾.舒胃汤对功能性消化不良大鼠
血清干细胞因子、一氧化氮的影响[J].湖南中医药大学学报英文版,2011,31(9):27-30.[Click to copy
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| 舒胃汤对功能性消化不良大鼠
血清干细胞因子、一氧化氮的影响 |
| 郭漩、弭艳红、王小娟、谭华梁、郭建生、徐寅、张鑫、饶文娟、李永静、郭蕾蕾 |
| ((1湖南中医药大学，湖南长沙410208;2湖南中医药大学第一附属医院，湖南长沙410007)) |
| 摘要: |
| 〔摘要〕目的观察舒胃汤对功能性消化不良(FD)大鼠血清干细胞因子(SCF)、一氧化氮(NO)的影响，探讨舒
胃汤治疗FD的作用机制、方法将60只SD大鼠随机分为空白组、模型组、术香顺气丸组、莫沙必利组、舒胃汤低
剂量组、舒胃汤高剂量组共6组，每组10只、除空白组外其余5组通过夹尾刺激方法制造功能性消化不良模型、模
型组和空白组不给予药物处理，其余各组大鼠分别给予相应药物灌胃治疗14 d}采用ELASA法检测大鼠血清
SCF,硝酸还原酶法检测大鼠血清NO含量变化〔结果与空白组比较，模型组大鼠血清NO升高，SCF降低(均为P<
0.05)，差异有统计学意义;舒胃汤治疗后血清SCF升高(P<0.05) , NO降低差异有统计学意义(P<0.05)〔结论舒胃
汤能够调节功能性消化不良大鼠血浆NO,SCF水平的变化，恢复胃肠道运动功能，从而起到对功能性消化不良的
治疗作用、 |
| 关键词: 功能性消化不良 胃肠运动 舒胃汤 干细胞因子 一氧化氮 大鼠 柴胡 积实 |
| DOI： |
| |
| 基金项目:湖南省卫生厅中医药专项基金(2008025);长沙市科技局项日(K1001061-31) |
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| Effects of Shuwei decoction on serum stem cell factorsand nitric oxiode in functional indigestive rats |
| GUO Xuan，MI Yan-bong，WANG Xiao一uan，
XU Yin，ZHANG Xin，RAO Wen一uan，
TAN Hua-Bang，GUO Jan-sheng，
LI Yong一ing，GUO Lei-lei |
| ((1. TCM University of Hunan, Changsha, Hunan 410007, China;
2. First Affiliated Hospital, TCM University of Hunan, Changsha, Hunan 410007) |
| Abstract: |
| (Abstract〕 Objective To observe the influences of Shuwei decoction on the content of
scrU17
nIt门c
oxiode (NO) and stem cell factors
(SCF)
FD.
in functional dyspepsia (FD)
rats and
study the
divided
a('t -
ing mechanism of the decoction on
Methods
Sixty rats were
randomly
7n
[()‘()ntr() I
group,
model
dose
group,
Muxiang Shunqi pills
Shuwei decoction low dose
group,
Mosapride
Shuwei
All the
cept for
decoction high
group
group, 10 rats in each
group,
group.
rats except for
in control and
then, SCF were detected
Compared with control
in control group were
model groups, the rats
with ELASA and the
group, serum NO
induced the FD models by clasping their
were gmen
content of
increased
corresponding medicine in 14
tails.
days.
Ex-
An(]
serUn
NO with nitrate reductase. Results
significantly and serum SCF
in model group(P<0.05); After treatment with Shuwei decoction, the
serun
SCF obviously
decreased
increased |
| Key words: (Key words〕 functional dyspepsia gastrointestinal motility tors(SCF) n}tr}c
oxiode(NO) rats Bupleuri Radix Aurantii Fructus
Shuwei decoction stem cell fac-
Immaturus |
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