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陈楚淘
田浩梅
张泓 张
娟 蔡何凝 张雨辰 官均泰.针刺对大鼠局灶性脑缺血后神经功能缺损及
梗死面积的影响[J].湖南中医药大学学报英文版,2011,31(7):63-66.[Click to copy
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| 针刺对大鼠局灶性脑缺血后神经功能缺损及
梗死面积的影响 |
| 陈楚淘
田浩梅
张泓张
娟蔡何凝张雨辰官均泰 |
| ((1湖南中医药大学经穴脏腑相关重点研究室，湖南长沙410208;2湖南中医药大学针灸生物信息分析实验室，湖南长沙
410208;3.湖南中医药大学针推学院2008级研究生班，湖南长沙410208)) |
| 摘要: |
| 〔摘要〕目的探讨针刺大椎、百会、人中穴对脑缺血大鼠神经功能缺损评分、脑梗死面积比的影响、方法参照
ZeaLonga线拴法复制大脑中动脉缺血模型(MCAO), 40只SD大鼠随机分为假手术组、模型组、针刺穴位组(即穴位
组，穴取大椎、百会、人中)、针刺对照点组(即对照点组，穴取大椎、百会、人中左侧旁开0.3 cm处),6次针刺后，观
察神经功能缺损评分及1`TC染色检测梗死面积比评价、结果与假手术组比较，模型组大鼠神经功能缺损评分、梗
死面积比明显增高，差异有统计学意义(P<0.01)，而对穴位组、对照点组能不同程度地降低神经功能缺损评分，减少
梗死面积，差异有统计学意义(P<0.05 , P<0.01)，且穴位组优于对照点组，差异有统计学意义(P<0.05 )〔结论针刺大
椎、百会、人中穴可通过改善神经功能的缺损，减少脑梗死面积从而对脑具有保护作用、 |
| 关键词: 针刺 局灶性脑缺血 神经功能缺损评分 脑梗死 梗死面积比 大鼠 大椎 百会 人中 |
| DOI： |
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| 基金项目:国家自然科学青午基金项日((30901901);2007午湖南省研究生创新基金项日 |
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| Effects ofand infarctAcupuncture on neurologic impairmentsize after local cerebral ischemia in rats |
| CHEN Chu-tao, TIAN Hao-mei, ZHANG Hong, ZHANG Juan, CAI He-ning
ZHANG Yu-chen, GUAN Jun-tai |
| ((TCM University of Hunan, Changsha, Hunan, 410208, China)) |
| Abstract: |
| [Abstract ]
ment and infarct
Objective To cxpl<)二[he effects of acupuncture (EA)
()n
neurological impair-
size in rats
occlusion (MCAO) model was
after local cerebral ischemia. Methods
established by improved thread embolism
The middle cerebral
method according[()
artery
Zea-
Longa. 40 SD rats were randomly divided into 4 groups: sham一(operated group, model group,
acupuncture group using points Dazhui, Baihui and Renzhong and control group 0.3 cm laterally
[()points Dazhui, Baihui and Renzhong, 10 rats per group. The acupuncture effect was evaluated
by the scores of neurological impairment and detected the percentage of brain infarct area with
TTC after 6 times of acupunctures. Results The scores of neurological impairment and the per-
centage of brain infarct area in model group were increased significantly compared with sham-
operated group (P <0.01), but the scores were decreased compared with acupuncture group and control group(P<0.05, P<0.01)，and it was better in treatment group than that in control group
(P<0.05). Conclusion Acupuncturing points Dazhui, Baihui and Renzhong can protect brain func-
boning on improvement of neurological impairment. |
| Key words: acupuncture cerebral intarction infarct size
local
score ratro rats
cerebral ischemia neurological function deficits point Dazhui point Baihui point Renzhong |
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