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孙克民 王和鸣 陈文列 黄美雅.复方巴戟天合剂对大鼠激素性股骨头
缺血性坏死的组织学研究[J].湖南中医药大学学报英文版,2011,31(7):14-17.[Click to copy
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| 复方巴戟天合剂对大鼠激素性股骨头
缺血性坏死的组织学研究 |
| 孙克民王和鸣陈文列黄美雅 |
| (广东省深圳平乐骨伤科医院，广东深圳518010;福建中医药大学，福建福州350108
福建中西医结合研究院重点实验室，福建福州350108)) |
| 摘要: |
| 目的 探讨复方巴戟天合剂对激素性股骨头缺血性坏死大鼠股骨头的组织学影响、方法SD大白鼠72
只，随机分成正常组、模型组、对照组、治疗组，每组18只〔建立大鼠激素性股骨头缺血性坏死模型，对照组、治疗组
每口给药1次，于实验后第4,8,12周分3批处死动物，取股骨头空骨陷窝、成骨细胞、破骨细胞及胶原面积进行统
计学分析〔结果空骨陷窝率模型组与正常组差异有统计学意义(P<0.01) ,治疗组与对照组较模型组差异有统计学意
义}P<0.01);治疗组与对照组成骨细胞计数较模型组差异有统计学意义}P<0.01)，破骨细胞计数较模型组差异有统计
学意义(P<0.01);治疗组与对照组胶原面积百分比与模型组比较差异有统计学意义}P<0.01)〔结论复方巴戟天合剂
对激素性股骨头缺血性坏死有明显的预防和治疗作用、 |
| 关键词: 复方巴戟天合剂 股骨头坏死 组织学 实验研究 大鼠 巴戟天 淫羊藿 骨碎补 |
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| 基金项目:〕国家自然科学基金资助项日(30271630) |
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| Effects of compound Morinda mixture on histologicalchanges in rats with glucocorticoid-induced avascular necrosis of femoral head |
| SUN Ke-min, WANG He-ming, CHEN Wen-lie, HUANG Mei-ya |
| ((Shenzhen Pingle Orthopaedic Hospital, Shengzhen, Guangdong, 518010, China) |
| Abstract: |
| (Abstract〕 Objective To observe the effects of compound Morinda mixture on histological changes
in rats with glucocorticoid induced avascular necrosis of the femoral head (ANFI}. Methods Seventy two
rats were randomly divided into normal group, model group, control group and therapeutic group, 18 rats
each group. The rat models were established by injection of glucocorticoid. The rats
were given drugs by gastric infusion one time a day and were killed in the fourth, eighth and
twelfth week respectively. Then the histology changes of the femoral head were observed[()eval-
uate the empty lacunae osteoblasts/osteoclast and wcol. Results The difference between lacunar
bonerategroup and normal group was significant (P<0.01); between treatment and control groups
and model group were significant (P<0.01); the differences of osteoblast cell counts between treat-
ment and control groups and model group were significant (P<0.01) and the osteoclast cell counts
also were significant (P <0.01); The difference of wcol percentage between treatment
and control groups and model group were significant (P<0.01). Conclusion Compound Morin-da mixture
is remarkably preventive and therapeutic effects
()n
ANFH. |
| Key words: compound Morinda mixture osteonecrosis of femoral head histology experimental
research rats Morinda Epimedium Drynaria |
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