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朱克; 彭芝配; 张金慧; 李文龙; 肖瑞飞; 田志刚; 江壮岚; 滕久祥;.秦香止泻方对小鼠小肠推进功能及镇痛作用的机制研究[J].湖南中医药大学学报英文版,2011,31(5):23-25.[Click to copy
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This paper
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秦香止泻方对小鼠小肠推进功能及镇痛作用的机制研究 |
朱克;彭芝配;张金慧;李文龙;肖瑞飞;田志刚;江壮岚;滕久祥; |
(湖南中医药大学; 韶关医学院药学系药学教研室) |
摘要: |
目的探讨秦香止泻方对正常小鼠小肠推进功能及冰醋酸致痛的镇痛作用。方法 (1)将40只SPF级昆明小鼠随机分为空白对照组、秦香止泻方低、中、高剂量组,分别给药后灌服碳末,处死动物观察小肠碳末推进率:(2)将50只SPF级昆明小鼠分组给药方法同(1),给药后腹腔注射2 mL冰醋酸,观察第1次扭体时间和30 min内各组小鼠扭体次数。结果 (1)秦香止泻方低、中、高剂量组与空白对照组组比较,小肠推进率基本相同,差异无统计学意义(P>0.05);(2)秦香止泻方低、中、高剂量组、肠康片组与空白对照组比较,疼痛潜伏时间均较空白对照组延长,差异具有统计学意义(P<0.05);扭体次数相比差异具有统计学意义(P<0.01);秦香止泻方中、高剂量组与肠康片组比较,疼痛潜伏时间延长,扭体次数亦减少,差异具有统计学意义(P<0.05)。结论秦香止泻方对正常小鼠小肠推进功能无明显抑制及推进作用;秦香止泻方低、中、高剂量组与肠康片组比较,扭体次数明显减少,提示秦香止泻方具有较好的镇痛作用。 更多还原 |
关键词: 秦香止泻方 小肠碳末推进 抗炎镇痛 小鼠 秦皮 木香 |
DOI: |
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基金项目:长沙市科技局课题(K1009002-31) |
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Mechanism study of Qinxiang Zhixie decocti on promoting small intestine and analgesic effect in mice |
ZHU Ke,PENG Zhi-pei,LI Wen-long,XIAO Rui-fei,TIAN Zhi-gang, JIANG Zhuang-lan,TENG Jiu-xiang(TCM University of Hunan,Changsha,Hunan 410007,China) |
((TCM University of Hunan, Changsha, Hunan 410007, China)) |
Abstract: |
Objective To investigate the effect of Qinxiang Zhixie decoction
on promotrng small intestine and analgesic effect in mice. Methods
(1)40 SPF mice were randomly divided into control groups, and low, medium and high dose of QinXiang Zhixie groups
and high dose groups were nearly same (P>0.05). (2)
tablet group, the pain latency time in all low, medium
Compared with control and high dose groups group writhing medium 7nteStlne was loner (P<0.05), |
Key words: QinXiang Zhixie decoction carbon propelling in small intestine anti-inflammatory analgesic mice Fraxinus rhynchophylla Hance Aucklandia lappa Decne |
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