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徐琦； 尹抗抗； 谭达全； 邓冰湘；.麻黄加术汤对大鼠类风湿性关节炎模型作用机制的研究[J].湖南中医药大学学报英文版,2011,31(5):13-15.[Click to copy
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| 麻黄加术汤对大鼠类风湿性关节炎模型作用机制的研究 |
| 徐琦；尹抗抗；谭达全；邓冰湘； |
| (1湖南中医药大学2008级硕士研究生班，湖南长沙410007; 2湖南中医药大学，湖南长沙410208) |
| 摘要: |
| 目的探讨麻黄加术汤对类风湿性关节炎的作用机制。方法运用Ⅱ型胶原法建立Wistar大鼠类风湿性关节炎模型,采用麻黄加术汤给予干预,以甲氨喋呤片为阳性对照药。将大鼠随机分为空白组、模型组、甲氨喋呤组、麻黄加术汤组。检测大鼠血清炎性细胞因子IL-1β、TNF-α浓度,观察大鼠膝关节滑膜组织病理改变。结果麻黄加术汤可显著降低大鼠血清炎性细胞因子IL-1β、TNF-α的含量,差异具有统计学意义(P<0.01),对CIA大鼠滑膜组织的炎性细胞浸润、纤维组织增生和巨噬样A型细胞有明显抑制作用,差异具有统计学意义(P<0.01)。结论麻黄加术汤治疗类风湿性关节炎的机制可能与降低炎性因子IL-1β、TNF-α的水平,抑制炎性细胞浸润、纤维组织增生和巨噬样A型细胞增生有关。 更多还原 |
| 关键词: 麻黄加术汤 类风湿性关节炎 IL-1β TNF-α 滑膜组织 大鼠 麻黄 桂枝 杏仁 |
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| 基金项目:湖南省科技厅资助项目(2008SK3071) |
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| Mmechanism study of Mahuang Jiazhu decoction on rheumatoid arthritis model in rats |
| XU Qi,YIN Kang-kang,TAN Da-quan,DENG Bing-xiang(TCM University of Hunan,Changsha,Hunan 410007,China) |
| ((TCM University of Hunan，Changsha，Hunan 410007，China)) |
| Abstract: |
| Objective To investigate the mechanism of Mahuang Jiazhu decoction on rheumatoid arthritis. Methods The arthritis models of Wistar rats were stablished by the type II collagen, the decoction was given[()be therapeutic drug, and methotrexate tablets was used as a positive control. The rats were randomly divided into control group, model group, methotrexate group, the decoction group. The serum concentration of inflammatory cytokines IL一1 [3 TNF一。，and the synovial tissue pathology in knee joint was measured. Results The decoction significantly reduced the serum levels of inflammatory cytokines IL-1(3 and TNF一。content of synovial (P<0.01), and inhibited significantly the CIA infiltration of inflammatory cells, fibrous tissue hyperplasia and macrophage-like cells-A significantly (P<0.01). Conclusion The mechanism of the decoction for rheumatoid arthritis maybe related[()二、Iuce the inflammatory factor IL-1(3 and TNF一。lev- els, inhibit the inflammatory cells infiltration, fibrous tissue hyperplasia and macrophage-like cell proliferation-A. |
| Key words: Mahuang Jiazhu decoction rheumatoid arthritis iL-1p TNF-cx rats Chinese ephedra cassia twig almond |
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