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邱赛红’，李琳’，朱传湘’，吴红娟’，滕健2，谢昭明3.盐酸青藤碱加离子导入法
对透皮吸收的影响[J].湖南中医药大学学报英文版,2011,31(3):36-38.[Click to copy
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| 盐酸青藤碱加离子导入法
对透皮吸收的影响 |
| 邱赛红’，李琳’，朱传湘’，吴红娟’，滕健2，谢昭明3 |
| (湖南中医药大学
;湖南省正清制药集团股份有限公司
;湖南省中医药研究院) |
| 摘要: |
| 〔摘要〕目的研究盐酸青藤碱的透皮吸收及离子导入方法对透皮吸收的影响、方法采用家兔离体皮肤及
Franz扩散池进行体外透皮试验，并以电子治疗仪作为外加电场进行离子导入，观测盐酸青藤碱注射液的透皮渗透
率，并比较外加电场对其透皮渗透量的影响、结果盐酸青藤碱的透皮量随着时间的延长而增加，符合零级动力学
方程( R==0.952 1)、外加电场可增加其透皮吸收量，其中以电场强度20 mA、通电时间15 min的透皮量较为I}想、
结论盐酸青藤碱注射液可透皮吸收，电场导入对其透皮吸收有一定的促进作用、木研究为临床中以盐酸青藤碱注
射液进行离子导入的治疗方法提供了实验依据、 |
| 关键词: 盐酸青藤碱 透皮吸收 离子导入 兔 大鼠 |
| DOI： |
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| 基金项目:湖南省高等学校科研项日((09C734) |
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| Effect of Sinomenine Hydrochloride with iontophoresison transdermal permeability |
| QIU Sai-hong, LI Lin, ZHU Chuan-xiang, WU Hong-Juan, TENG Jian, XIE Zhao-ming |
| (TCM University of Hunan) |
| Abstract: |
| (Abstract〕 Objective To study the transdermal permeability of Sinomenine Hydrochloride
and effected by ion-introduction. Method The transdermal permeability was made by skin in vit-
ro in rabbits and Franz diffusion cells with Electric Therapeutic Equipment as apposition electri-
cal field[()use ion -introduction, the transdermal permeation rate of Sinomenine Hydrochloride
injection was measured[()compare the effect of the apposition electrical field affected on the
transdermal permeability. Result The transdermal permeation rate of Sinomenine Hydrochloride
was increased as time going on, which conformed[()zer(卜(order equation (R2=0.952 1), and the
electrical field added was increased the transdermal absorption quantum, when the electrical field
was 20 mA in 15 min, the transdermal absorption quantum was better. Conclusion Sinomenine
Hydrochloride injection can be absorpted transdermally and be promoted by the electrical field,
which provides an experimentation grounds for Sinomenine Hydrochloride injection using in ion-
introduction in clinic. |
| Key words: Sinomenine Hydrochloride transdermal permeability ion-introduction rabbits rats |
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