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胡梅’，刘群良’*，舒畅2，谭峰.还少丹对老年小鼠脂褐素含量和
DNA分子结构稳定性的影响[J].湖南中医药大学学报英文版,2011,31(3):33-35.[Click to copy
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| 还少丹对老年小鼠脂褐素含量和
DNA分子结构稳定性的影响 |
| 胡梅’，刘群良’*，舒畅2，谭峰 |
| (湖南中医药大学;北京师范大学) |
| 摘要: |
| 〔摘要〕目的研究还少月一对老龄小鼠脂褐素含量和DNA分子结构稳定性的影响、方法将36只昆明种老年
小鼠(20月龄)，按体质量随机分为3组，另设12只2月龄同种小鼠作为青年对照组，共4组:①老年对照组;②老
年还少月一组;③老年维生素E(VE)组;④青年对照组〔连续喂养10周后，采用荧光分光光度法测定脑组织的脂褐素
水平和肝组织DNA双链解旋剩余率;用紫外分光光度法测定肝组织DNA碱变性增色效应、结果青年对照组、老
年还少月一组、老年VE组的脂褐素含量明显低于老年对照组，差异有统计学意义(P<0.05;与老年对照组比较，青年
对照组和老年还少月一组的DNA碱变性增色效应明显降低，而DNA双链解旋剩余率显著增高，差异均具有统计学
意义(P<0.05，而老年VE组的差异无统计学意义(P>0.05、结论还少月一能有效降低脂褐素的含量，保护DNA结
构的稳定性，达到延缓衰老的目的、 |
| 关键词: 还少月一 脂褐素 DNA碱变性 增色效应 DNA双链解旋剩余率 小鼠 何首乌 肉从蓉 |
| DOI： |
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| 基金项目:湖南省教育厅资助项日(07C479) |
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| Effect of Huanshaodanand structure stabilitylipofuscin contentDNA in aging mice |
| HU Mei, LIU Qun-Bang, SHU Chang, TAN Feng |
| (TCM University of Hunan) |
| Abstract: |
| (Abstract〕 Objective To study the effect of Huanshaodan
()n
lipofuscin
content and struc-
ture stability of DNA in aging mice. Methods 36 aging I}unming
mine
(20months)
I}unming mice(2months) were randomly divided into
nUn
‘l。i
aging Huanshaodan
weeks, the content
group, aging vitamin E group
four
and
of lipofuscin in brain tissue and the
as following, aging
and 12
control
young
group,
control group. After feeding
rate of double-stranded DNA
liver tissue were
detected with fluorescence spectrometry methods and spectrometry DNA alka-
1i degeneration hyperchromic effect in
the aging control group, the content
shaodan group
1i degeneration
HuanShaoDan
agin只vitamin
F
liver tissue
of lipofuscin
group were
、、as
detected with UV. Result Compared with
in the young control group, the
significant decreased (P<0.05);
aging
DNA
Huan-
alka-
hyperchromic effect
、、as
obviously decreased in the control group
group and the surplus rate of double-stranded DNA was
0.05)，but in the aging vitamin E group was
n()
remarkable decrease
significant
(P>0.05)
and the aging
increased (P<
Conclusions
Huanshaodan
DNA, which
can
obviously reduce the lipofuscin content and protect the structure stability of
maybe
can
delay senile process. |
| Key words: Huanshaodan Lipofuscin DNA alkali degeneration hyperchromic effect DNA double-strand broken
mu}c polygonum multiflorum cistanche salsa |
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