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潘江’，章薇2*，葛卫军2，陈武善’，石文英’，潘纯’，罗容.改良永久性线栓法制作大鼠
大脑中动脉梗阻模型的探讨[J].湖南中医药大学学报英文版,2011,31(3):24-26.[Click to copy
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| 改良永久性线栓法制作大鼠
大脑中动脉梗阻模型的探讨 |
| 潘江’，章薇2*，葛卫军2，陈武善’，石文英’，潘纯’，罗容 |
| (湖南中医药大学
;湖南中医药大学第一附属医院) |
| 摘要: |
| 〔摘要〕目的研究改良线栓法制作大脑中动脉梗阻(MCAO)大鼠模型〔方法将20只SD大鼠分为Zea Longa
组(A组)、改良线栓法组(B组)，并对其造模手术时间、梗死体积、神经功能缺损评分进行比较〔结果改良永久性
线栓法制作大鼠MCAO模型所用时间与Zea Longa线栓法所需时间比较差异具有统计学意义(P<0.05 )，梗死体
积、神经功能缺损评分两者比较，差异无统计学意义(P>0.05 )、结论改良永久性线栓法能减少造模时间，提示其梗
死体积、神经功能缺损评分，差异无统计学意义(P>0.05 )，均提示其造模成功、 |
| 关键词: 大鼠MCAO模型 改良线栓法 脑缺血模型 |
| DOI： |
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| 基金项目:湖南省高校科技创新平台基金项日〔09k062) |
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| Study on modified permanent suture for preparation of middle cerebral artery obstruction model in rats |
| PAN Jiang, ZHANG Wei, GE Wei一un, CHEN Wu-sham SHI Wen-ying,
PAN Chun, LUO Rong |
| (TCM University of Hunan) |
| Abstract: |
| (Abstract〕 Objective To study a modified suture for preparation of middle cerebral artery
obstruction (MCAO) model in rats. Method 20 SD rats
、、ere
divide into
A) and modified suture
group (group B) and compare
the operating time
Zea Longa
infarction
group(group
volume and
neurologic deficits rate.
MCAO model was shorter
Results The time
than that in group
using modified permanent suture[()prepare the
A(P<0.05), the differences of infarction volume and
neurologic deficits score
The modified permanent
between the two groups were statistically significant(P>0.05). Conclusion
suture can
reduce the modeling time and not affect model made. |
| Key words: MCAO rats model modified
suture
method cerebral ischemia model |
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