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艾碧深’，赵国荣’*，贺又舜’，肖碧跃’，曾序求’，谢静2，刘娟’，告fs文辉’，李鑫辉.卫气营血阶段性与内毒素血症兔不同时相
症状、体征的相关性研究[J].湖南中医药大学学报英文版,2011,31(3):20-23.[Click to copy
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| This paper
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| 卫气营血阶段性与内毒素血症兔不同时相
症状、体征的相关性研究 |
| 艾碧深’，赵国荣’*，贺又舜’，肖碧跃’，曾序求’，谢静2，刘娟’，告fs文辉’，李鑫辉 |
| (湖南中医药大学
;湖南中医药大学第一附属医院) |
| 摘要: |
| 〔摘要〕目的观察内毒素血症兔不同时相的症状、体征动态变化，探讨其与卫气营血阶段性辨证及传变的相似
性〔方法将22只新西兰大耳白兔随机分成空白组8只和模型组14只，采用静脉注射大肠杆菌内毒素(LPS)的方法
建立内毒素血症模型，空白组注入等量无菌生理盐水，观察内毒素血症兔不同时相症状和体征动态变化，不同阶段
发热净增值的平均值(4T)〔结果(1)1阶段(注入大肠杆菌内毒素2 h),模型兔出现耸毛、发抖、喷嚏、流涕等症状〔
心率略增快，发热净增值(4T)比空白组升高，差异有统计学意义(P< 0.01)〔 (2)2阶段(攻毒后2-6 h),模型兔小便
黄、呼吸明显增快增粗、心率增快，耳廓发热、充血明显以及结膜充血,4T比前一阶段升高，差异有统计学意义(尸<
0.01)〔 (3)3阶段(攻毒后6-36 h),模型兔精神萎靡，活动度和灵敏度h降，出现便血、耳廓发凉、结膜充血明显，II
周青紫、耳廓青紫或有疲点疲斑、眼球突出、鼻哑 ,嗜睡、全身瘫软无力、角弓反张、抽搐和死亡，4T比前一阶段降
低，高于空白组，差异有统计学意义(P < 0.01)〔结论内毒素血症兔的症状、体征出现有规律性的阶段性表现，1阶段
(攻毒后2 h)与温病卫分证相关，2阶段(攻毒后2-6 h)与气分证相关，3阶段攻毒后6-36 h与营、血分证相关〔 |
| 关键词: 内毒素血症 温病 卫气营血 兔 |
| DOI： |
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| 基金项目:国家自然科学基金青午科学基金项日(30801473);湖南省自然科学基金项日(09JJ6041, OOJJY2034) ;湖南省、湖南中医药大学重点
学科资助 |
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| Correlation study of symptoms and signs of endotoxemia in different phasesin Wei-qi-ying-xue syndrome in rabbits |
| AI Bi-ehen，ZHA
XIE
O Guo-rong
Jing，LIU
，HE
Juan，
You-shun，XIAO Bi-yue，ZENG Xu-qiu，
GAO Wen-hui .LI Xin-hui |
| (TCM University of Hunan) |
| Abstract: |
| (Abstract〕 Objective To study the dynamic changes of symptoms and signs of endotoxemia
in different phases and its correlation of the differentiation and passing of Wei-qi-ying-xue syn-
drome in rabbit. Methods 22 rabbits were randomly divided into blank group with 8 rabbits
and model group with 14 rabbits. The endotoxemia rabbits in model group were induced by in-
jetting LPS and the rabbits in blank were given NS, then, the symptoms and signs, and the av-
erage of net heating value in different time were measured. Results 1) After modeling 2 hours,
the model rabbits appeared symptoms hair standing, trembling, sneeze and running nose, and
light rapid heart rate, the DT increased significantly that that in blank group(P<0.01). 2) After in-
jection 2}6 hours, symptoms yellow urine, deep and rapid respiration, rapid heart rate, ear, fever-
ish, hyperaemia and conjunctive hyperaemia appeared, the DT was higher than the first stage (P<
0.01). 3) After 6 }36 hours, spirits drooped, activity and sensitivity decreased, the symp-
toms hematochezia, cold ear, obvious conjunctiva hyperaemia, black and blue around mouth and
ears, protrusion of the eyeballs, nosebleed, drowsiness, weak and limp, opisthotonos, hyperspasmia
and appeared and even death, the D T was lower than former stage , but it was higher than that in
blank group (P<0.01). Conclusion the symptoms and signs of endotoxemia rabbits manifested peri-
od changed. The 1st stage 2 hours after infectionis similar[()Weifen syndrome, the 2nd 2}6 hours
after injection[()Qifen syndrome, and the 3rd stage 6 }36 hours after injection[()Yin沙n and
Xuefen syndrome. |
| Key words: endotoxemia acute
febrile disease Wei-qi-ying-xue differentiation rabbits |
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