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杨正望’，文炯2，张增玲2.补肾化癖方对PCOS大鼠卵巢颗粒细胞
CYP450表达的影响[J].湖南中医药大学学报英文版,2011,31(1):30-32.[Click to copy
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| This paper
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| 补肾化癖方对PCOS大鼠卵巢颗粒细胞
CYP450表达的影响 |
| 杨正望’，文炯2，张增玲2 |
| (1湖南中医药大学第一附属医院，湖南长沙410007;2湖南醒陵市中医院，湖南醒陵412200) |
| 摘要: |
| 〔摘要〕目的观察补肾化疲方对多囊卵巢综合征(PCOS)大鼠卵巢颗粒细胞CYP450蛋白表达的影响〔方法
运用补肾化疲方对PCOS模型大鼠进行干预后，采用免疫组化法观察卵巢颗粒细胞CYP450的蛋白表达〔结果模
型组与正常组比较，卵巢颗粒细胞CYP450的蛋白表达在表达面积及表达强度上均低于正常组，差异具有统计学
意义(P<0.01);补肾化疲方中、高、低剂量组及妈富降组用药后，卵巢颗粒细胞的CYP450的蛋白表达明显升高，差
异具有统计学意义(P<0.01, P<0.05);其中补肾化疲方中剂量对PCOS大鼠卵巢颗粒细胞CYP450的蛋白表达效果
最佳、结论补肾化疲方能增强PCOS大鼠卵巢颗粒细胞CYP450的蛋白表达，调节卵巢内分泌失调，改善PCOS高
雄血症.逆转卵泡的发育异常.使排卵成功、 |
| 关键词: 〔关键词〕补肾化疲方 补骨脂 冤丝子 泽兰 细胞色素P450芳香化酶 多囊卵巢综合征 大鼠 卵巢颗粒细
胞 |
| DOI： |
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| 基金项目:湖南省自然科学基金资助项日((OSJJ40027) |
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| Effects of Bushen Huayu decoction of CYP450 in ovarian granulosaonprotein expressioncells in PCOS rats |
| YANG Zheng-wang, WEN jiong, ZHANG Zeng-ling |
| ((First Affiliated Hospital, TCM University of Hunan, Changsha, Hunan 410007, China) |
| Abstract: |
| (Abstract〕 Objective To explore the effects of Bushen Huayu decoction (BHD) on protein
expression of CYP450 in ovarian granulosa cells in PCOS rats. Method BHD was used[()in-
terpose the rats and the protein expression of CYP450 was determined with immunohistochemi-
cal method. Results Compared with normal group, the protein expression of CYP450
in model group was lower (P<0.01); and in high, middle and low dosages of BHD groups and
western medicine group were obviously higher(P<0.01 or P<0.05), in which, in middle dosage of
BHD group was best. Conclusion BHD can increase the protein expression of CYP450 in PCOS
rats，regulate the maladjustment of incretion balance and improve hyperandrogenemia，rest<)二[he
abnormal growth of folliole and ensure the success of ovulation. |
| Key words: [ Key words ] Bushen
aromatase cytochrome P450 Huayu decoction Semen
psoraleae Semen
cuscutae herba lycopi polycystic ovary syndrome rats ovarian
}ranulosa cells |
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