| 引用本文: |
王一豪, 刘朝霞.基于“微生物-肠-脑轴”浅析“脑肠同治”防治溃疡性结肠炎[J].湖南中医药大学学报,2025,45(7):1386-1393[点击复制] |
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| 基于“微生物-肠-脑轴”浅析“脑肠同治”防治溃疡性结肠炎 |
| 王一豪,刘朝霞 |
| (黑龙江中医药大学, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 溃疡性结肠炎（UC）的发病机制尚未完全明确，临床以腹痛、腹泻、黏液脓血便为主要表现，具有难治愈、易反复、病程长的特点。现代研究发现，微生物-肠-脑轴（MGBA）功能失调在UC的病理生理中发挥关键作用。中医学“脑肠同治”理论与MGBA双向调控机制高度契合，认为情志失调导致的“肝郁脾虚”是连接心理应激与肠道炎症、调控MGBA的核心病理环节。本文以“脑肠同治”理论为基础，系统论述了中医药通过“疏肝理脾、调畅情志”与“分期论治、扶正祛邪”等策略，多靶点干预肠道微生态、神经-内分泌-免疫网络及肠道屏障功能，从而对MGBA整体调控，旨在为UC的防治提供新的思路与方法。 |
| 关键词: 溃疡性结肠炎 微生物-肠-脑轴 脑肠同治 中医药 肠道微生物 分期治疗 |
| DOI：10.3969/j.issn.1674-070X.2025.07.029 |
| 投稿时间：2025-01-09 |
| 基金项目:黑龙江省中医药科研项目（ZHY-008）。 |
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| Prevention and treatment of ulcerative colitis by "simultaneous treatment of brain and gut" based on "microbiota-gut-brain axis" |
| WANG Yihao, LIU Zhaoxia |
| (Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China;First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| The pathogenesis of ulcerative colitis (UC) remains largely unclear, with clinical manifestations primarily characterized by abdominal pain, diarrhea, and mucopurulent bloody stools. UC is notoriously difficult to cure, prone to recurrence, and follows a chronic course. Modern research has revealed that dysfunction of the microbiota-gut-brain axis (MGBA) plays a pivotal role in the pathophysiology of UC. The TCM theory of "simultaneous treatment of brain and gut" highly corresponds with the bidirectional regulatory mechanisms of the MGBA, positing that "liver stagnation with spleen deficiency" caused by emotional dysregulation acts as the core pathological link connecting psychological stress with intestinal inflammation and MGBA regulation. Based on this theory, this study systematically elucidates how TCM employs strategies such as "soothing the liver and rectifying the spleen, regulating emotions" and "staged treatment, reinforcing healthy qi to eliminate pathogenic factors" to intervene at multiple targets. These approaches modulate intestinal microecology, the neuro-endocrine-immune network, and intestinal barrier function, thereby achieving holistic regulation of the MGBA. The aim is to provide new insights and methods for the prevention and treatment of UC. |
| Key words: ulcerative colitis microbiota-gut-brain axis simultaneous treatment of brain and gut Chinese medicine gut microbiota staged treatment |
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