| 引用本文: |
李灵凌, 于宗良, 张子浩, 李晓雅, 刘昕怡, 袁永芳, 吴敏, 刘龙涛.基于“血脉癥积”理论探讨动脉粥样硬化铜死亡机制的中医病机及辨治策略[J].湖南中医药大学学报,2025,45(7):1325-1331[点击复制] |
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| 基于“血脉癥积”理论探讨动脉粥样硬化铜死亡机制的中医病机及辨治策略 |
| 李灵凌,于宗良,张子浩,李晓雅,刘昕怡,袁永芳,吴敏,刘龙涛 |
| (中国中医科学院西苑医院, 中医证候全国重点实验室, 国家中医心血管病临床医学研究中心, 北京 100091;北京中医药大学研究生院, 北京 100029;中国中医科学院广安门医院, 北京 100053) |
| 摘要: |
| 动脉粥样硬化（AS）是一种以慢性炎症反应为特征的血管病理改变。铜死亡是一种由细胞内铜离子过量积累导致的细胞死亡形式，与AS的发生发展密切相关，通过诱导脂质沉积、炎症浸润、平滑肌细胞异常增殖及氧化应激反应等参与AS的发生与发展。基于“血脉癥积”理论，本团队认为AS的病机为元气亏虚、因虚致瘀，瘀滞久蕴、化毒致变，瘀毒胶结、积而成癥。在“血脉癥积”理论指导下，结合铜死亡在AS中的作用机制，本团队提出补虚逐瘀、活血解毒、软坚消癥法论治AS。本研究以“血脉癥积”为切入点，在“虚、瘀、毒”理论指导下，阐释AS铜死亡机制的中医内涵并探讨中医诊疗思路，旨在为AS的中医药治疗提供理论依据和辨治策略。 |
| 关键词: 动脉粥样硬化 血脉癥积 铜死亡机制 “虚、瘀、毒”病机 补虚逐瘀法 活血解毒法 软坚消癥法 |
| DOI：10.3969/j.issn.1674-070X.2025.07.019 |
| 投稿时间：2025-03-25 |
| 基金项目:国家科技重大专项项目（2024ZD0522004）；北京市自然科学基金项目（7242257）；首都卫生发展科研专项项目（2022-2-4172）；中国中医科学院西苑医院提升中医药临床循证证据级别研究专项（XYZX0201-09）。 |
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| TCM pathogenesis and differentiated treatment strategies for cuproptosis mechanisms in atherosclerosis based on the theory of "blood vessel stagnation and accumulation" |
| LI Lingling, YU Zongliang, ZHANG Zihao, LI Xiaoya, LIU Xinyi, YUAN Yongfang, WU Min, LIU Longtao |
| (National Clinical Research Center for Chinese Medicine Cardiology, State Key Laboratory of Traditional Chinese Medicine Syndrome, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China;Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China) |
| Abstract: |
| Atherosclerosis (AS) is a vascular pathological condition characterized by chronic inflammatory responses. Cuproptosis, a form of cell death induced by excessive intracellular copper ion accumulation, is closely associated with the onset and progression of AS. It participates in AS development by promoting lipid deposition, inflammatory infiltration, abnormal proliferation of smooth muscle cells, and oxidative stress reactions. Based on the theory of "blood vessel stagnation and accumulation," our team proposes that the pathogenesis of AS involves deficiency of Yuan-primordial qi, leading to blood stasis prolonged stagnation transforming into toxins, causing pathological changes; and the conglomeration of stasis and toxins, resulting in the formation of accumulations. Guided by this theory and integrating the mechanistic role of cuproptosis in AS, a therapeutic approach is advocated for treating AS, which involves tonifying deficiency and eliminating stasis, activating blood circulation to remove toxins, and softening hardness and resolving accumulations. This study takes "blood vessel stagnation and accumulation" as the entry point, elucidates the TCM connotations of cuproptosis mechanisms in AS under the guidance of the "deficiency, stasis, and toxin" theory, and explores TCM diagnostic and therapeutic strategies. The aim is to provide theoretical foundations and differentiated treatment strategies for TCM interventions in AS. |
| Key words: atherosclerosis blood vessel stagnation and accumulation cuproptosis mechanism pathogenesis of "deficiency, stasis and toxin" tonifying deficiency and eliminating blood stasis activating blood circulation to remove toxins softening hardness and resolving accumulations |
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