| 引用本文: |
张静, 王海燕.基于虚、瘀、毒病机的中药活性成分干预卵巢癌作用机制研究进展[J].湖南中医药大学学报,2026,46(9):1953-1962[点击复制] |
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| 基于虚、瘀、毒病机的中药活性成分干预卵巢癌作用机制研究进展 |
| 张静,王海燕 |
| (海口市人民医院, 海南 海口 570208) |
| 摘要: |
| 立足卵巢癌虚、瘀、毒的病机理论，系统梳理补虚、活血、解毒三类代表性中药活性成分的最新基础研究成果，从调控程序性细胞死亡、介导关键信号通路、重塑肿瘤微环境、抑制肿瘤侵袭转移、逆转化疗及靶向耐药等多方面深入分析各类中药活性成分干预卵巢癌的分子作用机制，阐释中医病机理论与现代抗肿瘤机制的科学关联性。补虚类中药活性成分扶正固本，通过调节免疫与代谢、重塑抗肿瘤微环境，以改善正气亏虚之本；活血类中药活性成分化瘀通脉，通过抑制血管新生、阻断上皮-间质转化、减少肿瘤侵袭转移，以破除瘀血内阻之基；解毒类中药活性成分清解癌毒，通过诱导铁死亡、凋亡等程序性细胞死亡并逆转化疗及靶向药物耐药，以清除癌毒蕴结之标。三类成分通过多靶点、多通路协同配伍，可阻断虚、瘀、毒相互滋生的恶性循环，为卵巢癌的中西医结合个体化治疗及天然抗肿瘤活性药物研发提供参考。 |
| 关键词: 卵巢癌|虚|瘀|毒|病因病机|中药活性成分|信号通路|研究进展 |
| DOI：10.3969/j.issn.1674-070X.2026.09.030 |
| 投稿时间：2026-07-11 |
| 基金项目:海南省自然科学基金项目(824RC561);海南省卫生健康科技创新联合项目(WSJK2024QN067)。 |
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| Research progress on the mechanisms of action of active components of Chinese medicine monomers in ovarian cancer intervention based on the pathogenesis theory of deficiency, stasis, and toxin |
| ZHANG Jing, WANG Haiyan |
| (Haikou People's Hospital, Haikou, Hainan 570208, China) |
| Abstract: |
| Based on the pathogenesis theory of deficiency, stasis, and toxin in ovarian cancer, this paper systematically reviews the latest basic research findings on three representative categories of active components of Chinese medicines—those that tonify deficiency, circulate blood, and remove toxin. It analyzes the molecular mechanisms of action by which various active components of Chinese medicines intervene in ovarian cancer from multiple aspects, including regulating programmed cell death, mediating key signaling pathways, remodeling the tumor microenvironment, inhibiting tumor invasion and metastasis, and reversing chemotherapy and targeted drug resistance. It also elucidates the scientific correlation between TCM pathogenesis theory and modern anti-tumor mechanisms. Active components of tonic medicines can reinforce healthy qi to strengthen the body, ameliorating the root deficiency of healthy qi by regulating immunity and metabolism and remodeling the tumor microenvironment. Active components of blood-circulating medicines can transform stasis and unblock vessels, breaking the basis of internal blood stasis obstruction by inhibiting angiogenesis, blocking epithelial-mesenchymal transition, and reducing tumor invasion and metastasis. Active components of toxin-removing medicines can clear and resolve cancer toxin, eliminating the manifestation of accumulated cancer toxin by inducing programmed cell death such as ferroptosis and apoptosis and reversing resistance to chemotherapy and targeted therapy. Through multi-target and multi-pathway synergistic compatibility, these three categories of components can block the malignant process in which deficiency, stasis, and toxin intermingle and aggravate each other in a cascade, providing a reference for individualized integrated Chinese and Western medicine treatment of ovarian cancer and for the development of natural anti-tumor active drugs. |
| Key words: ovarian cancer|deficiency|stasis|toxin|etiology and pathogenesis|active components of Chinese medicines|signaling pathways|research progress |
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