| 引用本文: |
胡梦婉, 尤磊, 杨钰琪, 范若竹, 吴限.针刺调控BDNF/TrkB通路治疗卒中后痉挛的研究进展[J].湖南中医药大学学报,2026,46(7):1528-1534[点击复制] |
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| 针刺调控BDNF/TrkB通路治疗卒中后痉挛的研究进展 |
| 胡梦婉,尤磊,杨钰琪,范若竹,吴限 |
| (黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001;黑龙江省中医药科学院, 黑龙江 哈尔滨 150036;黑龙江中医药大学, 黑龙江 哈尔滨 150006;黑龙江中医药大学附属第一医院, 黑龙江 哈尔滨 150040) |
| 摘要: |
| 卒中后痉挛（PSS）是脑卒中后常见的运动功能障碍，严重影响患者运动功能恢复与生活质量。其病理机制涉及中枢抑制能力下降、脊髓环路重构等多重因素，临床治疗难度较大。针刺治疗PSS临床疗效确切，脑源性神经营养因子（BDNF）及其受体酪氨酸激酶受体B（TrkB）介导的BDNF/TrkB信号通路在调控突触可塑性、维持神经元存活中发挥重要作用。本文以BDNF/TrkB信号通路为切入点，系统梳理针刺通过调控该通路改善PSS的作用机制，以期为针刺治疗PSS的机制研究与临床应用提供理论依据。 |
| 关键词: 卒中后痉挛|针刺|BDNF/TrkB信号通路|神经保护与再生|突触可塑性 |
| DOI：10.3969/j.issn.1674-070X.2026.07.030 |
| 投稿时间：2026-02-02 |
| 基金项目:国家中医药管理局第三届国医大师传承工作室及全国名中医传承工作室建设项目（国中医药办人教〔2018〕119号）；黑龙江省中医药经典普及化专项课题（ZYW2023-040）。 |
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| Research progress on acupuncture in the treatment of post-stroke spasticity through regulation of the BDNF/TrkB pathway |
| HU Mengwan, YOU Lei, YANG Yuqi, FAN Ruozhu, WU Xian |
| (The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150001, China;Heilongjiang Academy of Chinese Medical Sciences, Harbin, Heilongjiang 150036, China;Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150006, China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China) |
| Abstract: |
| Post-stroke spasticity (PSS) is a common motor dysfunction following stroke that severely impairs motor recovery and quality of life. Its pathological mechanisms involve multiple factors, including reduced central inhibitory control and remodeling of spinal neural circuits, bringing great difficulties to clinical treatment. Acupuncture has demonstrated favorable clinical efficacy in treating PSS. The signaling pathway mediated by brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin receptor kinase B (TrkB), plays an important role in regulating synaptic plasticity and promoting neuronal survival. Focusing on the BDNF/TrkB signaling pathway, this paper systematically summarizes the potential mechanism of action by which acupuncture alleviates PSS through modulation of this pathway, with the aim of providing a theoretical basis for further mechanistic research and the clinical application of acupuncture in the management of PSS. |
| Key words: post-stroke spasticity|acupuncture|BDNF/TrkB signaling pathway|neuroprotection and regeneration|synaptic plasticity |
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