| 引用本文: |
荆晓朔, 蔡瑾, 魏彦柏, 杨萍, 晏峻峰.青少年抑郁症肝郁脾虚证眼动特征研究[J].湖南中医药大学学报,2026,46(7):1444-1451[点击复制] |
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| 青少年抑郁症肝郁脾虚证眼动特征研究 |
| 荆晓朔,蔡瑾,魏彦柏,杨萍,晏峻峰 |
| (湖南中医药大学中医学院, 湖南 长沙 410208;湖南省智慧中医工程技术研究中心, 湖南 长沙 410208;湖南中医药大学信息科学与工程学院, 湖南 长沙 410208;湖南省脑科医院, 湖南 长沙 410021) |
| 摘要: |
| 目的 探讨青少年抑郁症肝郁脾虚证患者的眼动特征，为该病的早期诊断提供客观依据。方法 研究选取青少年抑郁症肝郁脾虚证患者与健康青少年各36例，采用先进眼动追踪系统，通过注视点稳定性、朝向反向眼跳和平滑追踪3项任务采集眼动数据，分析总注视时间、眼跳幅度等眼动特征的差异。结果 与健康对照组相比，病例组在3项眼动任务中均表现出显著的眼动差异（P＜0.05），具体表现为：在注视点稳定性任务中的总注视时间显著缩短、眼跳次数增多、眼跳幅度增大；在朝向反向眼跳任务中眼跳正确率显著降低、眼跳潜伏期明显延长；在平滑追踪任务中总注视时间减少、速度增益与位置差值增大。结论 青少年抑郁症肝郁脾虚证患者存在特征性眼动异常，因此，眼动特征可作为青少年抑郁症肝郁脾虚证中医辨证的潜在客观生物标记，为抑郁症的客观诊断及中医理论现代化提供参考。 |
| 关键词: 抑郁症|肝郁脾虚证|青少年|眼动特征|眼跳 |
| DOI：10.3969/j.issn.1674-070X.2026.07.017 |
| 投稿时间：2025-11-10 |
| 基金项目:湖南省教育厅科学研究重点项目（23A0312）。 |
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| Eye movement characteristics of adolescents with depression of liver stagnation and spleen deficiency pattern |
| JING Xiaoshuo, CAI Jin, WEI Yanbai, YANG Ping, YAN Junfeng |
| (School of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Engineering Research Center for Intelligent Chinese Medicine, Changsha, Hunan 410208, China;School of Information Science and Engineering, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Provincial Brain Hospital, Changsha, Hunan 410021, China) |
| Abstract: |
| Objective To explore the eye movement characteristics of adolescents with depression of liver stagnation and spleen deficiency pattern, and to provide objective evidence for the early diagnosis of this condition. Methods Thirty-six adolescents with depression of liver stagnation and spleen deficiency pattern and 36 healthy adolescents were enrolled. Eye movement data were collected using an advanced eye-tracking system during three tasks: fixation stability, prosaccade/antisaccade, and smooth pursuit. Differences in eye movement parameters, including total fixation duration and saccade amplitude, were analyzed. Results Compared with the healthy control group, the patient group exhibited significant abnormalities in eye movement parameters across all three tasks (P<0.05). During the fixation stability task, the patient group had a significantly shorter total fixation duration, a greater number of saccades, and a larger saccade amplitude. During the prosaccade/antisaccade task, the patient group had a significantly lower correct saccade rate and a longer saccade latency. During the smooth pursuit task, the patient group showed a shorter total fixation duration, higher velocity gain, and a greater positional difference. Conclusion Adolescents with depression of liver stagnation and spleen deficiency pattern exhibit characteristic eye movement abnormalities. These characteristics may serve as potential objective biomarkers for TCM pattern differentiation, thereby providing a reference for the objective diagnosis of depression and the modernization of TCM theory. |
| Key words: depression|liver stagnation and spleen deficiency pattern|adolescents|eye movement characteristics|saccade |
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