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刘雅华, 侯宇佳, 杨传琦, 芦殿荣, 夏玉清.电热针对气血两虚型癌因性疲乏患者中医证候及血清学指标的影响[J].湖南中医药大学学报,2025,45(12):2335-2339[点击复制] |
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| 电热针对气血两虚型癌因性疲乏患者中医证候及血清学指标的影响 |
| 刘雅华,侯宇佳,杨传琦,芦殿荣,夏玉清 |
| (北京中医药大学研究生院, 北京 100029;中国中医科学院望京医院肿瘤科, 北京 100102;北京市通州区潞城社区卫生服务中心, 北京 101117;中国中医科学院望京医院电热针科, 北京 100102) |
| 摘要: |
| 目的 探讨电热针刺关元、水道及提托穴对气血两虚型癌因性疲乏患者的中医证候及血清学指标的影响。方法 将66例住院化疗患者随机分为对照组（33例）与电热针组（33例）。对照组接受常规对症处理（包括药物止痛、止吐等），电热针组在常规处理基础上，加用电热针刺关元、双侧水道及双侧提托穴，每日1次，连续治疗7 d。于治疗前后记录两组患者的中医证候积分；评估临床疗效；于治疗前后检测两组患者血清C-反应蛋白（CRP）、促甲状腺激素（TSH）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）及干扰素-γ（IFN-γ）水平；试验过程进行安全性评价。结果 治疗后，电热针组中医证候积分较治疗前降低（P＜0.01），且低于对照组（P＜0.01）。电热针组总有效率75.8%，高于对照组的42.4%（P＜0.05）。对照组IL-6较治疗前升高（P＜0.05）；电热针组IFN-γ较治疗前降低（P＜0.05），且低于对照组（P＜0.05），CRP、TSH、TNF-α指标差异均无统计学意义（P＞0.05）。试验期间，两组患者均未出现与针灸相关的不良反应。结论 电热针刺关元、水道及提托穴可有效缓解气血两虚型癌因性疲乏患者的疲乏状态及相关证候，其作用机制可能与影响IL-6和IFN-γ水平有关。 |
| 关键词: 电热针 癌因性疲乏 气血两虚证 白细胞介素-6 干扰素-γ |
| DOI：10.3969/j.issn.1674-070X.2025.12.012 |
| 投稿时间：2025-07-01 |
| 基金项目:北京中医药薪火传承“3+3”工程建设项目夏玉清名老中医传承工作室（京中医科字〔2021〕73号）；中国中医科学院望京医院院级课题（WJYY-XZKT-2023-20）。 |
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| Effects of electrothermal acupuncture on Chinese medicine pattern and serological indicators in patients with cancer-related fatigue of dual deficiency of qi and blood pattern |
| LIU Yahua, HOU Yujia, YANG Chuanqi, LU Dianrong, XIA Yuqing |
| (Graduate School of Beijing University of Chinese Medicine, Beijing 100029, China;Department of Oncology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China;Lucheng Community Health Center of Tongzhou District, Beijing 101117, China;Department of Electrothermal Acupuncture, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing 100102, China) |
| Abstract: |
| Objective To investigate the effects of electrothermal acupuncture at Guanyuan (CV4), Shuidao (ST28), and Tituo (Ex-CA9) points on Chinese medicine pattern and serological indicators in patients with cancer-related fatigue (CRF) of dual deficiency of qi and blood pattern. Methods Sixty-six hospitalized patients undergoing chemotherapy were randomly divided into control group (n=33) and electrothermal acupuncture group (n=33). The control group received conventional symptomatic treatment (including analgesic and antiemetic medications), while the electrothermal acupuncture group received conventional treatment plus electrothermal acupuncture at Guanyuan (CV4), bilateral Shuidao (ST28), and bilateral Tituo (Ex-CA9) points, once daily for seven consecutive days. Chinese medicine pattern scores, clinical efficacy was evaluated, and serum levels of C-reactive protein (CRP), thyroid-stimulating hormone (TSH), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) were measured in both groups before and after treatment; safety evaluation was performed throughout the trial. Results After treatment, the Chinese medicine pattern scores in the electrothermal acupuncture group were significantly lower than those before treatment (P<0.01) and also lower than those in the control group (P<0.01). The total effective rate in the electrothermal acupuncture group was 75.8%, which was significantly higher than the 42.4% in the control group (P<0.05). In the control group, IL-6 levels increased compared to those before treatment (P<0.05). In the electrothermal acupuncture group, IFN-γ levels decreased compared to those before treatment (P<0.05) and were lower than those in the control group (P<0.05). No statistically significant differences were observed in CRP, TSH, and TNF-α levels (P>0.05). No acupuncture-related adverse reactions occurred in either group during the trial. Conclusion Electrothermal acupuncture at Guanyuan (CV4), Shuidao (ST28), and Tituo (Ex-CA9) points can effectively alleviate fatigue and related patterns in patients with CRF of dual deficiency of qi and blood pattern. The mechanism of action may be associated with the modulation of IL-6 and IFN-γ levels. |
| Key words: electrothermal acupuncture cancer-related fatigue dual deficiency of qi and blood pattern interleukin-6 interferon-γ |
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