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阳睦贤, 邹会品, 肖明珠, 贾瑶, 张忠勤, 周逸群, 石继连.厚朴饮片质量等级标准综合评分机制研究[J].湖南中医药大学学报,2025,45(4):654-661[点击复制] |
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| 厚朴饮片质量等级标准综合评分机制研究 |
| 阳睦贤,邹会品,肖明珠,贾瑶,张忠勤,周逸群,石继连 |
| (湖南中医药大学药学院, 湖南 长沙 410208;国家中医药管理局湖南中医药大学中药炮制技术传承基地, 湖南 长沙 410208;湖南振兴中药有限公司, 湖南 长沙 410208) |
| 摘要: |
| 目的 基于数据分析软件分析生厚朴饮片质量，建立饮片质量等级标准综合评分机制。方法 对市售的17批生厚朴饮片的外观性状指标、醇浸出物、灰分、厚朴酚、和厚朴酚、紫丁香苷、木兰花碱及其挥发性成分等进行测定。使用SPSS 23.0软件对数据进行相关性分析；结合SIMCA 14.1软件进行主成分分析和正交偏最小二乘法判别分析，筛选影响饮片质量的差异性指标。结合K-值聚类分析并引入层次分析法建立厚朴饮片综合质量等级评价体系。结果 对收集的指标数据进行统计分析，最终确定厚朴的差异性指标为：色度值L*和b*、和厚朴酚、浸出物，可将厚朴饮片划分为三等：一等品总得分＞110分；二等品总得分90~110分；三等品总得分＜90分。结论 建立的综合评分机制能有效区分不同厚朴饮片的质量，为饮片质量等级标准制定提供科学依据。 |
| 关键词: 厚朴 等级标准 主成分分析 正交偏最小二乘法判别分析 评分机制 |
| DOI：10.3969/j.issn.1674-070X.2025.04.010 |
| 投稿时间：2025-01-03 |
| 基金项目:湖南省自然科学基金项目（2023JJ50445）；湖南振兴中药有限公司横向课题。 |
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| Comprehensive scoring mechanism of quality grade standard of Houpo Decoction-ready Medicines |
| YANG Muxian, ZOU Huipin, XIAO Mingzhu, JIA Yao, ZHANG Zhongqin, ZHOU Yiqun, SHI Jilian |
| (School of Pharmacy, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Chinese Medicine Processing Technology Heritage Base of Hunan University of Chinese Medicine, State Administration of Traditional Chinese Medicine, Changsha, Hunan 410208, China;Hunan Zhenxing Chinese Medicine Co., LTD, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To analyze the quality of Houpo Decoction-ready Medicines based on various data analysis softwares, and to establish a comprehensive scoring mechanism for the quality grade standard of decoction-ready medicines. Methods Measure was made on 17 batches of Houpo Decoction-ready Medicines from the market for their appearance traits, alcohol extract, ash, magnolol, honokiol, syringin, magnoliine, and volatile components. SPSS 23.0 software was used for correlation analysis of the data, combined with SIMCA 14.1 software for principal component analysis and orthogonal partial least squares discriminant analysis (OPLS-DA) to screen the difference indexes affecting their quality. The comprehensive quality grade evaluation system of Houpo Decoction-ready Medicines was established using the analytic hierarchy process combined with K-value cluster analysis. Results Statistical analysis of the collected index data finds out that the difference indexes of Houpo (Magnolia Officinalis) were determined as L*, b*, magnolol, and extract. Houpo Decoction-ready Medicines could be divided into three grades in accordance with the total scores with the first grade>110 points, the second grade 90-110 points, and the third grade<90 points. Conclusion The established comprehensive scoring mechanism can effectively distinguish the quality of different Houpo Decoction-ready Medicines and provide scientific basis for the formulation of quality grade standards of decoction-ready medicines. |
| Key words: Houpo (Magnolia officinalis) grade standard principal component analysis orthogonal partial least squares-discriminant analysis scoring mechanism |
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