| 引用本文: |
宁彩红, 彭坷平, 田桂湘, 田道法, 王少波, 彭书旺.益气养阴解毒方加减用于放化疗后气阴两虚、毒热蕴肺证鼻咽癌患者的增效减毒效应观察[J].湖南中医药大学学报,2025,45(1):158-163[点击复制] |
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| 益气养阴解毒方加减用于放化疗后气阴两虚、毒热蕴肺证鼻咽癌患者的增效减毒效应观察 |
| 宁彩红,彭坷平,田桂湘,田道法,王少波,彭书旺 |
| (湖南中医药大学第一附属医院, 湖南 长沙 410007;中南大学湘雅二医院, 湖南 长沙 410011) |
| 摘要: |
| 目的 探讨益气养阴解毒方加减用于放化疗后气阴两虚、毒热蕴肺证鼻咽癌患者的增效减毒效应。方法 选取2022年1月至2024年1月纳入湖南中医药大学第一附属医院鼻咽癌患者80例，按随机数字表法分为观察组、对照组，均40例。对照组给予放化疗治疗，观察组在对照组基础上联合益气养阴解毒方加减治疗。比较两组临床疗效及中医证候积分，同时检测其血清炎症因子指标[C反应蛋白（CRP）、白细胞介素（IL）-6、转化生长因子-β1(TGF-β1)、IL-8、降钙素原（PCT）]，另外评估两组患者放射性口腔黏膜炎分级，最后比较其不良反应。结果 观察组客观缓解率（85.0%）和疾病控制率（95.0%）明显高于对照组的65.0%和72.5%(P<0.05)；两组治疗后鼻塞涕血、口咽干燥、耳鸣耳聋、时有头痛、舌红、脉细数积分明显低于治疗前（P<0.05），且观察组低于对照组（P<0.05）；两组炎症因子各指标均较治疗前降低，且观察组低于对照组（P<0.05）；治疗后，两组放射性口腔黏膜炎分级改善情况优于治疗前，且观察组优于对照组（P<0.05）；观察组不良反应总发生率低于对照组（P<0.01）。结论 益气养阴解毒方加减不仅可改善患者放化疗后气阴两虚、毒热蕴肺证鼻咽癌患者临床症状、体征及炎症反应，还可减轻口腔黏膜损伤，减少不良反应。 |
| 关键词: 益气养阴解毒方 放化疗 鼻咽癌 气阴两虚 毒热蕴肺 |
| DOI：10.3969/j.issn.1674-070X.2025.01.026 |
| 投稿时间：2024-09-23 |
| 基金项目:国家自然科学基金青年项目(82002397);湖南省教育厅科学研究青年项目(22B0402)。 |
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| Observation on the synergistic and toxic attenuating effects of modified Yiqi Yangyin Jiedu Formula on nasopharyngeal carcinoma patients with qi and yin deficiency and toxic-heat accumulating in the lung patterns after radiochemotherapy |
| NING Caihong, PENG Keping, TIAN Guixiang, TIAN Daofa, WANG Shaobo, PENG Shuwang |
| (The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China) |
| Abstract: |
| Objective To explore the synergistic and toxic attenuating effects of the modified Yiqi Yangyin Jiedu Formula（YQYYJDF） on nasopharyngeal carcinoma（NPC） patients with qi and yin deficiency and toxic-heat accumulating in the lung patterns after radiochemotherapy. Methods Eighty NPC patients in the First Hospital of Hunan University of Chinese Medicine from January 2022 to January 2024 were randomly divide d into observation group and control group by random number table method, with 40 patients in each group. The control group received radiochemotherapy, while the observation group was treated with the modified YQYYJDF on the basis of the control group. Clinical efficacy and Chinese medicine（CM） pattern scores were compared between the two groups. Meanwhile, serum inflammatory factor indicators, including C-reactive protein（CRP）, interleukin-6（IL-6）, transforming growth factor-β1（TGF-β1）, interleukin-8（IL-8）, and procalcitonin（PCT）, were measured. The grades of radiationinduced oral mucositis were assessed in both groups, and their adverse reactions were compared. Results The objective remission rate（85.00%） and disease control rate（95.00%） in the observation group were significantly higher than those in the control group（65.00%and 72.50% respectively）（P＜0.05）. After the treatment, the scores for nasal congestion with blood-tinged discharge, oropharynx dryness, tinnitus and hearing loss, intermittent headaches, red tongue, and thin rapid pulse were significantly lower in both groups than those before treatment（P＜0.05）, with the observation group showing more significant improvements（P＜0.05）. Inflammatory factor indicators were significantly reduced in both groups after treatment, with the observation group showing lower levels compared to the control group（P＜0.05）. After treatment, the grades of radiation-induced oral mucositis improved in both groups, with the observation group demonstrating superior improvement（P＜0.05）. The overall incidence of adverse reactions in the observation group was significantly lower than that in the control group（P＜0.01）. Conclusion The modified YQYYJDF can not only effectively alleviate clinical symptoms, signs, and inflammatory reactions in NPC patients with patterns of qi and yin deficiency and toxic-heat accumulating in the lung after radiochemotherapy, but also alleviate oral mucosal injury and reduce adverse reactions. |
| Key words: Yiqi Yangyin Jiedu Formula radiochemotherapy nasopharyngeal carcinoma qi and yin deficiency toxic-heat accumulating in the lung |
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