| 引用本文: |
李梦恩, 石林, 李思议, 崔源, 向昱阳, 刘禹.胫骨横向骨搬移术联合象皮生肌膏治疗糖尿病足的临床观察[J].湖南中医药大学学报,2024,44(6):1068-1073[点击复制] |
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| 胫骨横向骨搬移术联合象皮生肌膏治疗糖尿病足的临床观察 |
| 李梦恩,石林,李思议,崔源,向昱阳,刘禹 |
| (湖南中医药大学, 湖南 长沙 410208;重庆市垫江县中医院, 重庆 408300;重庆医科大学, 重庆 400016;四川省中西医结合医院, 四川 成都 610042) |
| 摘要: |
| 目的 观察胫骨横向骨搬移术联合象皮生肌膏治疗糖尿病足的临床疗效。方法 将纳入研究的60例糖尿病足患者用随机数字表非盲法分为观察组和对照组，每组30例。对照组行胫骨横向骨搬移术合并常规换药治疗，观察组在对照组的基础上联合象皮生肌膏外涂治疗。观察两组患者创面肉芽组织出现时间、创面愈合时间、完成横向骨搬移术全程（31 d）后的临床疗效，入院当天及完成横向骨搬移术全程（31 d）后踝肱指数（ankle brachial index, ABI）、疼痛视觉模拟量表（visual analogue scale, VAS）评分、患足皮温，以及血管内皮生长因子（vascular endothelial growth factor, VEGF）、白细胞介素6（interleukin-6, IL-6）、C反应蛋白（C-reactive protein, CRP）的水平。结果 治疗后，观察组临床总有效率优于对照组（P<0.05）；观察组创面肉芽组织出现时间、创面愈合时间均较对照组缩短（P<0.05）；观察组ABI、患足皮温、VEGF水平均较对照组升高（P<0.05）；观察组患者VAS评分及IL-6、CRP水平均较对照组降低（P<0.05）。结论 胫骨横向骨搬移术联合象皮生肌膏治疗糖尿病足可提高临床疗效，加速创面肉芽组织生长，促进创面愈合，改善下肢血液循环，降低血清CRP、IL-6水平，缓解创面疼痛。 |
| 关键词: 糖尿病足 胫骨横向骨搬移术 象皮生肌膏 炎症因子 血管内皮生长因子 |
| DOI：10.3969/j.issn.1674-070X.2024.06.019 |
| 投稿时间：2023-11-12 |
| 基金项目:重庆市科卫联合医学科研项目（2022MSXM170）。 |
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| Clinical observation of transverse tibial bone transport combined with Xiangpi Shengji Ointment in treating diabetic foot |
| LI Meng'en, SHI Lin, LI Siyi, CUI Yuan, XIANG Yuyang, LIU Yu |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Chongqing Dianjiang County Hospital of Chinese Medicine, Chongqing 408300, China;Chongqing Medical University, Chongqing 400016, China;Sichuan Hospital of Integrated Chinese and Western Medicine, Chengdu, Sichuan 610042, China) |
| Abstract: |
| Objective To observe the clinical efficacy of transverse tibial bone transport combined with Xiangpi Shengji Ointment (XPSJO) in treating diabetic foot (DF). Methods Sixty DF patients included in the study were divided into observation group and control group by random number table non-blind method, with 30 cases in each group. The control group was treated with transverse tibial bone transport combined with conventional dressing change, while the observation group was given external application of XPSJO on the basis of the control group. The emergence time of wound granulation tissue, wound healing time, clinical efficacy after completing the whole process of transverse tibial bone transport (31 d), as well as the ankle brachial index (ABI), visual analogue scale (VAS) pain score, foot skin temperature, the levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6), and C-reactive protein (CRP) after admission and completing the whole process of transverse bone transport (31 d) were observed in both groups. Results After treatment, the total clinical effective rate of the observation group was higher than that of the control group (P<0.05). The emergence time of wound granulation tissue and wound healing time in the observation group were shorter than those in the control group (P<0.05). The ABI, foot skin temperature, and VEGF level in the observation group were higher than those in the control group (P<0.05). The VAS score and levels of IL-6 and CRP in the observation group were lower than those in the control group (P<0.05). Conclusion Transverse tibial bone transport combined with XPSJO can enhance the clinical efficacy of DF, accelerate the growth of wound granulation tissue, promote wound healing, improve blood circulation in lower limbs, reduce serum CRP and IL-6 levels, and alleviate wound pain. |
| Key words: diabetic foot transverse tibial bone transport Xiangpi Shengji Ointment inflammatory factor vascular endothelial growth factor |
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