| 引用本文: |
吴正飞,谢丽萍,黄盼黎,莫姿姿,张樱芳.基于肠道菌群探讨中医药治疗慢性肾衰竭的研究进展[J].湖南中医药大学学报,2023,43(8):1531-1535[点击复制] |
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| 基于肠道菌群探讨中医药治疗慢性肾衰竭的研究进展 |
| 吴正飞,谢丽萍,黄盼黎,莫姿姿,张樱芳 |
| (广西中医药大学研究生院, 广西 南宁 530001;广西中医药大学第一附属医院, 广西 南宁 530002) |
| 摘要: |
| 肠道菌群与慢性肾衰竭（chronic renal failure，CRF）之间存在双向调节：一方面，肠源性尿毒症毒素（gut-derived uremic toxin，GDUT）直接影响CRF的进展；另一方面，CRF患者的肠道微生态紊乱，大量GDUT产出。肠道菌群是循环发生的始动因子，肠道微生态紊乱使肠毒素累积，进而引起肠道屏障的破坏，大量肠毒素入血，引发一系列与肾脏相关的炎症、氧化、促纤维化机制反应，导致CRF进展。基于中医药研究现状，查阅相关文献，通过综述硫酸吲哚酚、硫酸对甲酚和氧化三甲胺等主要GDUT影响CRF的作用机制，并探讨中医药治疗基于肠道菌群干预CRF进展的研究现状，为未来临床疾病的治疗提供参考。 |
| 关键词: 肠道菌群 慢性肾衰竭 肠源性尿毒症毒素 中医药治疗 研究进展 |
| DOI：10.3969/j.issn.1674-070X.2023.08.029 |
| 投稿时间：2023-03-25 |
| 基金项目:广西重点研发计划项目（桂科计字〔2020〕159号）。 |
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| Research progress on Chinese medicine in treating chronic renal failure based on intestinal flora |
| WU Zhengfei,XIE Liping,HUANG Panli,MO Zizi,ZHANG Yingfang |
| (Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China;The First Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530002, China) |
| Abstract: |
| There is a dual-direction regulation between intestinal flora and chronic renal failure (CRF). On the one hand, gut-derived uremic toxin (GDUT) directly affect the progress of CRF. On the other hand, the intestinal microecology of CRF patients is in disorder, and a large number of GDUT are produced. Intestinal flora is the initial factor of this circulation. Intestinal microecological disorder causes the accumulation of enterotoxins, which in turn causes the destruction of the intestinal barrier. A large number of enterotoxins enter the blood, triggering a series of kidney-related reactions including inflammation, oxidation, and pro-fibrosis, leading to the progress of CRF. Based on the current research status of Chinese medicine and relevant literature, the action mechanism of main GDUT which affect CRF such as indoxyl sulfate, p-cresol sulfate and trimethylamine oxide was reviewed, and the research status of Chinese medicine in the intervention of CRF progress based on intestinal flora was discussed, so as to provide reference for the treatment of clinical diseases in the future. |
| Key words: intestinal flora chronic renal failure gut-derived uremic toxins Chinese medicine treatment research progress |
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