| 引用本文: |
孙伍慧,姚思凡,张艺,赵碧清.天然药物中抗乙型肝炎病毒活性成分研究进展[J].湖南中医药大学学报,2023,43(8):1536-1546[点击复制] |
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| 天然药物中抗乙型肝炎病毒活性成分研究进展 |
| 孙伍慧,姚思凡,张艺,赵碧清 |
| (湖南中医药大学, 湖南 长沙 410208) |
| 摘要: |
| 乙型肝炎病毒（hepatitis B virus，HBV）是引起乙型肝炎的病原体，具有传染性强、发病率高和流行范围广等特点，严重威胁着人类的健康。目前临床使用的药物存在着较大缺陷，迫切需要更为高效安全的抗HBV新药，研究天然药物及其活性成分抗HBV已经成为一种趋势。通过查阅近十年文献，对天然药物中抗HBV活性单体成分的研究概况进行整理，按化学类别分类，总结出97个活性显著、靶点独特的天然药物活性成分及衍生物，主要包括苯丙素类、黄酮类、生物碱类、萜类等，并对HBV的感染与抑制机制进行归纳。旨在阐述抗HBV活性成分的新发现，为今后开发新的抗HBV药物提供参考。 |
| 关键词: 天然药物 抗乙型肝炎病毒 活性成分 作用机制 研究进展 |
| DOI：10.3969/j.issn.1674-070X.2023.08.030 |
| 投稿时间：2022-12-09 |
| 基金项目:湖南省教育厅科学研究项目（19K067）；湖南中医药大学中药学一流学科项目（2018ZYX01）。 |
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| Research progress on active ingredients of anti-hepatitis B virus in natural medicines |
| SUN Wuhui,YAO Sifan,ZHANG Yi,ZHAO Biqing |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| As the pathogen of hepatitis B, hepatitis B virus (HBV) is characterized by strong infectivity, high morbidity, and wide prevalence, which seriously threatens human health. Currently, there are significant deficiencies in the clinical use of drugs against it, and more efficient and safer new anti-HBV drugs are urgently needed. It has become a trend to study natural medicines and their active ingredients against HBV. By consulting the literature in the past decade, the research progress on the active ingredients of anti-HBV in natural medicines was reviewed. According to chemical categories, 97 active ingredients and derivatives of natural medicines with notable activity and unique targets were summarized, mainly including phenylpropanoids, flavonoids, alkaloids, terpenoids, and others. Meanwhile, the mechanisms of HBV infection and inhibition were also summarized. This paper aims to elaborate the new findings of anti-HBV active ingredients and provide reference for the development of new anti-HBV drugs in the future. |
| Key words: natural medicines anti-hepatitis B virus active ingredients mechanism of action research progress |
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