| 引用本文: |
纪柯伊,吴宿慧,李寒冰,李根林.基于中医“祛腐生肌”理论探讨自噬在溃疡性结肠炎中的作用及中药干预的研究进展[J].湖南中医药大学学报,2023,43(5):955-960[点击复制] |
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| 基于中医“祛腐生肌”理论探讨自噬在溃疡性结肠炎中的作用及中药干预的研究进展 |
| 纪柯伊,吴宿慧,李寒冰,李根林 |
| (河南中医药大学, 河南 郑州 450046;河南中医药大学, 河南 郑州 450046;河南省健康衰老产业工程研究中心, 河南 郑州 450046) |
| 摘要: |
| 自噬是一种细胞自我保护和自我更新的机制,与溃疡性结肠炎(ulcerative colitis, UC)的发生发展密切相关。中医"祛腐生肌"理论常用于疮疡病的治疗。在一定程度上,UC的自噬机制与中医"祛腐生肌"理论有着相互贯通之处。自噬是机体对于"腐""生"两者的调控机制,存在双向调节关系,即自噬通过对损伤细胞或组织起到清除(祛腐)的作用,从而对机体肠道细胞起到一定的保护作用,同时为"生肌"提供基础和条件。基于此现状,对UC、自噬、中医"祛腐生肌"理论三者之间的关系进行系统阐述,为此类疾病的治疗及研究提供参考与启发。 |
| 关键词: 溃疡性结肠炎 中医药 祛腐生肌 自噬 作用机制 |
| DOI：10.3969/j.issn.1674-070X.2023.05.030 |
| 投稿时间：2023-02-06 |
| 基金项目:河南省科技攻关计划（21210230347）；河南中医药大学2022年度研究生科研创新类项目（2022KYCX004）。 |
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| Effects of autophagy in ulcerative colitis and research progress of TCM intervention based on theory of “eliminating necrotic tissues and regenerating new tissues” |
| JI Keyi,WU Suhui,LI Hanbing,LI Genlin |
| (Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China;Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China;Henan Engineering Research Center of Healthy Aging Industry, Zhengzhou, Henan 450046, China) |
| Abstract: |
| Autophagy is a mechanism of cellular self-protection and self-renewal and is closely related to the onset and development of ulcerative colitis (UC). The TCM theory of "eliminating necrotic tissues and regenerating new tissues" is commonly applied in treating ulcerative diseases. To a certain extent, the autophagy mechanism of UC is interlinked with the TCM theory of "eliminating necrotic tissues and regenerating new tissues". Autophagy is the body's self-regulatory mechanism for both "necrosis" and "regenerating", which manifested as a bidirectional regulation, that is, autophagy can protect the body's intestinal cells by removing damaged cells or tissues (eliminating necrotic tissues), and provides the basis for "regenerating new tissues" simultaneously. Based on this situation, this paper has systematically elaborated the relationship among UC, autophagy, and the theory of "eliminating necrotic tissues and regenerating new tissues", thus providing reference and inspiration for the treatment and research of these diseases. |
| Key words: ulcerative colitis Chinese medicine eliminating necrotic tissues and regenerating new tissues autophagy mechanism of action |
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