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魏敏,陈思洁,李成艳.脐灸联合黄芪建中汤对脾胃虚寒型胃脘痛患者临床疗效及机制研究[J].湖南中医药大学学报,2020,40(12):1499-1503[点击复制] |
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| 脐灸联合黄芪建中汤对脾胃虚寒型胃脘痛患者临床疗效及机制研究 |
| 魏敏,陈思洁,李成艳 |
| (枣庄市中医医院脾胃病科, 山东 枣庄 277800) |
| 摘要: |
| 目的 探讨脐灸联合黄芪建中汤对胃脘痛脾胃虚寒型患者临床疗效及机制。方法 选择2017年1月至2020年1月在本院接受治疗的88例脾胃虚寒型胃脘痛患者，采用随机数字表法将患者分为对照组和观察组，每组44例。对照组行常规西医治疗，观察组在此基础上加以脐灸联合黄芪建中汤治疗。比较2组患者临床疗效、中医证候评分、睡眠质量、血清学指标及不良反应发生情况。结果 观察组患者总有效率为95.45%，高于对照组的81.82%（P<0.05）。治疗后，两组患者中医证候评分及睡眠质量评分均较治疗前明显下降，且观察组低于对照组（P<0.05）；两组患者白细胞介素4（interleukin 4，IL-4）、白细胞介素6（interleukin 6，IL-6）均较治疗前明显下降，且观察组低于对照组（P<0.05）；两组患者表皮生长因子（epidermal growth factor，EGF）均较治疗前明显升高，且观察组高于对照组（P<0.05）。两组不良反应发生率比较，差异无统计学意义（P>0.05）。结论 常规西医治疗上采用脐灸联合黄芪建中汤治疗较单独使用西医治疗可明显提高脾胃虚寒型胃脘痛患者临床疗效，改善患者中医证候及睡眠质量，其作用机制可能与缓解炎症反应、提高EGF水平有关。 |
| 关键词: 胃脘痛 脾胃虚寒 脐灸 黄芪建中汤 中医证候评分 睡眠质量 |
| DOI：10.3969/j.issn.1674-070X.2020.12.012 |
| 投稿时间：2020-09-14 |
| 基金项目:山东省中医药科技发展计划项目（2019-0640）。 |
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| Study on Clinical Efficacy and the Mechanism of Umbilical Moxibustion Combined with Huangqi Jianzhong Decoction in Patients with Stomach Pain of Deficient Cold of Spleen and Stomach Syndrome |
| WEI Min,CHEN Sijie,LI Chengyan |
| (Department of Spleen and Stomach Diseases, Zaozhuang Hospital of Traditional Chinese Medicine, Zaozhuang, Shandong 277800, China) |
| Abstract: |
| Objective To explore clinical efficacy and the mechanism of umbilical moxibustion combined with Huangqi Jianzhong Decoction in patients with stomach pain of deficient cold of spleen and stomach type. Methods From January 2017 to January 2020, 88 patients with stomach pain of deficient cold of spleen and stomach type treated in our hospital were selected. The random number table method was used to assign the patients into a control group and a observation group, with 44 cases in each group. The control group was given conventional western medicine treatment, and the observation group was also given umbilical moxibustion combined with Huangqi Jianzhong Decoction on the basis of conventional western medicine treatment. Clinical efficacy, TCM syndrome scores, sleep quality, serological indicators and adverse reactions in the 2 groups were compared. Results The total effective rate in the observation group was 95.45%, which was higher than 81.82% in the control group (P<0.05). After the treatment, the scores of TCM syndromes and the scores of the Athens Insomnia Scale were decreased significantly in the 2 groups, compared with those before the treatment, and the decrease in the observation group was greater than that in the control group (P<0.05). The interleukin 4 (IL-4) and interleukin 6 (IL-6) in the 2 groups were decreased significantly, compared with those before the treatment, and the decrease in the observation group was greater than that in the control group (P<0.05). The epidermal growth factor(EGF) levels in the 2 groups were increased significantly, compared with those before the treatment, and the increase in the observation group was greater than that in the control group (P<0.05). In comparison on occurrence rates of adverse reactions in the 2 groups, there was no statistically significant difference (P>0.05). Conclusion Compared with applying western medicine treatment alone, umbilical moxibustion combined with Huangqi Jianzhong Decoction based on conventional western medicine treatment can significantly improve the clinical efficacy, the TCM syndrome and the sleep quality in patients with stomach pain of deficient cold of spleen stomach type. The mechanism of action may be related to alleviation of inflammatory reaction and improvement of the EGF level. |
| Key words: stomach pain deficient cold of spleen and stomach umbilical moxibustion Huangqi Jianzhong Decoction TCM syndrome score Athens Insomnia Scale |
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