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钟达源,李兰,蒋成婷,邓奕辉.6种活血化瘀中药复方联合西药治疗缺血性脑卒中的网状Meta分析[J].湖南中医药大学学报,2019,39(9):1114-1119[点击复制] |
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| 6种活血化瘀中药复方联合西药治疗缺血性脑卒中的网状Meta分析 |
| 钟达源,李兰,蒋成婷,邓奕辉 |
| (湖南中医药大学中西医结合学院, 湖南 长沙 410208) |
| 摘要: |
| 目的 对6种活血化瘀中药复方联合西药治疗缺血性中风进行网络荟萃分析，寻找改善缺血性中风症状的最佳复方。方法 计算机检索中国生物医学文献服务系统、中国知网、万方数据库和维普数据库，搜索6种活血化瘀中药复方治疗缺血性中风的随机对照试验（RCT），检索时间为从建库起至2019年4月3日，由两名研究者分别对文献质量进行严格评价并进行数据提取后录入Gemtc软件，用R3.5.2软件调用Gemtc数据进行网状Meta分析。结果 纳入文献18篇，涉及7个干预措施；2 083位患者。网状Meta分析结果显示，通窍活血汤联合西药组在降低NIHSS评分方面效果最佳，补阳还五汤联合西药在提高ADL评分方面效果最佳，益气活血汤联合西药在降低中医证候积分方面效果最佳，益气活血汤联合西药组在降低神经功能缺损评分方面效果最佳。结论 对于缺血性中风患者，西药治疗加用活血化瘀中药复方的治疗效果均优于单纯西药治疗；在西药治疗的基础上加用通窍活血汤、补阳还五汤或益气活血汤，患者获得最优治疗效果的可能性最高。 |
| 关键词: 缺血性中风 活血化瘀中药 网状Meta分析 贝叶斯模型 |
| DOI：10.3969/j.issn.1674-070X.2019.09.014 |
| 投稿时间：2019-05-17 |
| 基金项目:国家自然科学基金面上项目（81874416）；湖南省教育厅科学研究项目（16K063）。 |
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| Compound Prescriptions with 6 Kinds of Chinese Materia Medica for Promoting Blood Circulation and Removing Blood Stasis Combined with Western Medicine in Ischemic Stroke: A Network Meta-analysis |
| ZHONG Dayuan,LI Lan,JIANG Chengting,DENG Yihui |
| (Hunan University of Chinese Medicine, Changsha, Hunan 410208, China) |
| Abstract: |
| Objective To conduct a network meta-analysis on compound prescriptions with 6 kinds of Chinese materia medica (CMM) for promoting blood circulation and removing blood stasis combined with western medicine in the treatment of ischemic stroke, and to find the best compound prescription for improving the symptoms of ischemic stroke. Methods A computer-based retrieval of SinoMed, CNKI, Wanfang Data and VIP was conducted for randomized controlled trials of compound prescriptions with 6 kinds of CMM for promoting blood circulation and removing blood stasis in the treatment of ischemic stroke. The retrieval time was from the establishment of the database to April 3rd, 2019. Two researchers separately evaluated the quality of the literature and extracted the data into Gemtc software, and R3.5.2 software was used to call the Gemtc data for network meta-analysis. Results Eighteen papers were included, involving 7 interventions and 2083 patients. The results of network meta-analysis showed that Tongqiao Huoxue Decoction combined with western medicine group had the best effect in decreasing NIHSS score; Buyang Huanwu Decoction combined with western medicine had the best effect in increasing ADL score; Yiqi Huoxue Decoction combined with western medicine had the best effect in decreasing traditional Chinese medicine (TCM) syndrome score; and Yiqi Huoxue Decoction combined with western medicine group had the best effect in decreasing neurological deficit score. Conclusion For patients with ischemic stroke, the therapeutic effect of western medicine combined with CMM compound prescriptions for promoting blood circulation and removing blood stasis is better than that of western medicine alone. On the basis of western medicine treatment, if Tongqiao Huoxue Decoction, Buyang Huanwu Decoction or Yiqi Huoxue Decoction is added, the patient is most likely to have the best therapeutic effect. |
| Key words: Chinese materia medica for promoting blood circulation and removing blood stasis ischemic stroke network meta-analysis Bayesian models |
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