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赵咏梅,汪志凌.神曲消食口服液治疗小儿脾胃虚弱型功能性消化不良的疗效观察[J].湖南中医药大学学报,2019,39(3):409-412[点击复制] |
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| 神曲消食口服液治疗小儿脾胃虚弱型功能性消化不良的疗效观察 |
| 赵咏梅,汪志凌 |
| (成都市龙泉驿区妇幼保健院儿科, 四川 成都 610100;四川大学华西第二医院, 四川 成都 610041) |
| 摘要: |
| 目的 分析神曲消食口服液治疗小儿脾胃虚弱型功能性消化不良的临床疗效。方法 将90例功能性消化不良患儿按随机数字表法分为对照组和观察组各45例，两组均采用一般生活干预措施，对照组联合枸橼酸莫沙必利进行治疗，观察组联合神曲消食口服液进行治疗，比较两组临床疗效、临床症状评分、消化功能指标（胃泌素、胃动素）含量、近端胃排空功能及不良反应发生情况。结果 观察组治疗有效率为80.0%，显著高于对照组68.89%，差异具有统计学意义（P<0.05）；治疗后两组临床症状评分较治疗前均降低（P<0.05），且观察组显著低于对照组（P<0.05）；治疗后两组患儿胃泌素、胃动素含量较治疗前均升高（P<0.05），且观察组显著高于对照组（P<0.05）；治疗后，不同餐后时间点比较，观察组的胃排空功能明显优于对照组（P<0.05）；治疗过程中，两组不良反应发生率比较差异无统计学意义（P>0.05）。结论 神曲消食口服液治疗小儿脾胃虚弱型功能性消化不良临床效果好，可显著提高胃泌素、胃动素水平，明显增强胃排空功能，值得临床推广。 |
| 关键词: 功能性消化不良 儿童 脾胃虚弱证 神曲消食口服液 |
| DOI：10.3969/j.issn.1674-070X.2019.03.027 |
| 投稿时间：2018-05-08 |
| 基金项目:四川省科技厅重点研发项目（2018SZ0130） |
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| Clinical Efficacy of Shenqu Xiaoshi Oral Liquid in Children with Functional Dyspepsia Due to Spleen-Stomach Deficiency Syndrome |
| ZHAO Yongmei,WANG Zhiling |
| (Department of Pediatrics, Maternal and Child Health Hospital of Longquanyi District, Chengdu, Sichuan 610100, China;West China Second University Hospital, Sichuan University Chengdu, Sichuan 610041, China) |
| Abstract: |
| Objective To investigate the clinical efficacy of Shenqu Xiaoshi oral liquid in children with functional dyspepsia due to spleen-stomach deficiency syndrome. Methods A total of 90 children with functional dyspepsia were randomly assigned to lifestyle intervention combined with mosapride citrate (control group, n=45) or lifestyle intervention combined with Shenqu Xiaoshi oral liquid (observation group, n=45). The two groups were compared in terms of clinical outcome, symptom score, the levels of digestive function markers (gastrin and motilin), proximal gastric emptying function, and the incidence of adverse reactions. Results The response rate of the observation group was significantly higher than that of the control group (80.0% vs 68.89%, P<0.05). The symptom scores in both groups were significantly decreased after treatment (P<0.05), and the score in the observation group was significantly lower than that in the control group (P<0.05). Both groups showed significant increases in the levels of gastrin and motilin after treatment (P<0.05), and their levels were significantly higher in the observation group than in the control group (P<0.05). After treatment, the observation group had significantly better gastric emptying function than the control group at different time points after meal. There was no significant difference in the incidence of adverse reactions between the two groups during the treatment (P>0.05). Conclusion Shenqu Xiaoshi oral liquid has good clinical efficacy in children with functional dyspepsia due to spleen-stomach deficiency syndrome. It can significantly increase the levels of gastrin and motilin and gastric emptying function, and thus holds promise for clinical application. |
| Key words: functional dyspepsia child spleen-stomach deficiency syndrome Shenqu Xiaoshi oral liquid |
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