| 引用本文: |
吴艳,吴勉华.癌毒病机理论辨治恶性肿瘤的研究进展[J].湖南中医药大学学报,2018,38(10):1217-1220[点击复制] |
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| 癌毒病机理论辨治恶性肿瘤的研究进展 |
| 吴艳,吴勉华 |
| (南京中医药大学, 江苏 南京 210023;江苏省中医药防治肿瘤协同创新中心, 江苏 南京 210023) |
| 摘要: |
| 癌毒病机是国医大师周仲瑛提出的肿瘤病机理论，癌毒与痰、瘀、湿等病理因素相互转化、交替因果、共同为病，构成恶性肿瘤的复合病机。消癌解毒方和癌痛平胶囊是周教授在癌毒理论指导下临床应用的经验复方制剂，体内及体外研究证实两者以多途径、多靶点的方式起到提高免疫、减轻毒副作用，通过调控基因、上调蛋白进而诱导凋亡在抗肿瘤方面有显著成效。本文综述消癌解毒方和癌痛平胶囊抗肿瘤的机制，并在免疫功能及炎性信号通路方面继续深入探讨。 |
| 关键词: 癌毒病机理论 消癌解毒方 癌痛平 抗肿瘤 综述 |
| DOI：10.3969/j.issn.1674-070X.2018.10.028 |
| 投稿时间：2018-03-15 |
| 基金项目:国家自然科学基金项目资助（81774266）；国家自然科学基金青年科学基金项目（81703758）。 |
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| Advances in Research on Syndrome Differentiation and Treatment of Malignant Tumors Under the Guidance of Pathogenesis Theory of Cancerous Toxin |
| WU Yan,WU Mianhua |
| (Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, China;Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine for Prevention and Treatment of Tumor, Nanjing, Jiangsu 210023, China) |
| Abstract: |
| The pathogenesis theory of cancerous toxin is proposed by the Chinese medicine master Zhou Zhongying, who points out that cancerous toxin and other pathogenic factors like phlegm, stasis, and dampness together contribute to the pathogenesis of malignant tumors by mutual transformation, alternating causation, and comorbidity. Xiaoai Jiedu Prescription and Aitongping Capsule are two empirical compound formulations which are applied in clinical practice under the guidance of Professor Zhou's pathogenesis theory of cancerous toxin. In vivo and in vitro studies have confirmed that these two formulations have some effects in enhancing immunity and reducing toxic and side effects through involvement in various pathways and targets; meanwhile, the two formulations show significant antitumor effect by regulating gene expression and up-regulating the expression of proteins, thus inducing apoptosis. This article summarizes the antitumor mechanisms of Xiaoai Jiedu Prescription and Aitongping Capsule, which paves the way for further investigation of the clinical efficacy of the formulations from the aspects of immune function and inflammatory signaling pathways. |
| Key words: pathogenesis theory of cancerous toxin Xiaoai Jiedu Prescription Aitongping Capsule antitumor review |
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