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蒋军艳,李欣玲,樊泽锋,伍新诚,吴金玉.百令胶囊联合西药治疗慢性肾小球肾炎临床疗效的Meta分析[J].湖南中医药大学学报,2017,37(12):1363-1368[点击复制] |
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| 百令胶囊联合西药治疗慢性肾小球肾炎临床疗效的Meta分析 |
| 蒋军艳,李欣玲,樊泽锋,伍新诚,吴金玉 |
| (广西中医药大学研究生院, 广西 南宁 530001;广西中医药大学第一附属医院, 广西 南宁 530023) |
| 摘要: |
| 目的 系统评价百令胶囊联合西药治疗慢性肾小球肾炎的临床疗效。方法 计算机检索中国知网、万方、维普、PubMed及Embase等数据库，检索时间从建库至2016年6月，检索相关文献并筛选出百令胶囊联合西药治疗慢性肾小球肾炎的随机对照试验（RCT），并以Jadad量表进行质量评估和提取文献中的原始数据，运用RevMan5.3软件进行Meta分析。结果 共纳入18篇文献，1 274例患者，Meta分析结果显示，试验组治疗后有效率高于对照组［OR=3.26，95% CI（2.35，4.54）］（P<0.00001）；治疗后试验组24 h尿蛋白定量低于对照组［MD=-0.41，95% CI（-0.45，-0.37）］（P<0.00001）；治疗后试验组血肌酐低于对照组［MD=-17.27，95% CI（-22.63，-11.9］（P<0.00001）；治疗后试验组尿素氮低于对照组[MD=-1.60，95% CI（-2.14，-1.06）]（P<0.00001）。结论 百令胶囊联合西药治疗慢性肾小球肾炎的临床疗效优于常规的西药治疗，临床安全性好，但纳入该Meta分析的文献质量较低，发表文献存在一定偏倚性，因此，有待于更高质量的随机、多中心、双盲临床试验进行证实。 |
| 关键词: 慢性肾小球肾炎 百令胶囊 Meta分析 随机对照试验 |
| DOI：10.3969/j.issn.1674-070X.2017.12.016 |
| 投稿时间：2017-04-04 |
| 基金项目: |
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| Bailing Capsule Combined with Western Medicine in Treating Chronic Glomerulonephritis: A Meta-analysis |
| JIANG Junyan,LI Xinling,FAN Zefeng,WU Xincheng,WU Jinyu |
| (Graduate School, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, China;The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi 530023, China) |
| Abstract: |
| Objective To systemically evaluate the clinical treatment of Bailing capsule combined with Western medicine on chronic glomerulonephritis. Methods The database searched from the build up to June 2016 was searched from CNKI, Wanfang, VIP, PubMed and Embase. RCT of Bailing capsule in treating chronic glomerulonephritis were screened. Original data from the literatures was evaluated by Jadad scale, and performed for a Meta-analysis by using RevMan 5.3 software. Results 18 randomized controlled clinical trials, 1274 patients were included. Meta-analysis showed that the experimental group was more effective than the control group after treatment[OR=3.26, 95% CI (2.35, 4.54) (P<0.00001). After treatment, the 24 h proteinuria of the experimental group was lower than the control group[MD=-0.41, 95% CI (-0.45, -0.37)] (P<0.00001). After treatment, the serum creatinine was lower than the control group[MD=-17.27, 95% CI (-22.63, -11.9](P<0.00001). The urea nitrogen in the treatment group was lower than the control group[MD=-1.60, 95% CI (-2.14, -1.06)] (P<0.00001). Conclusion Bailing capsule combined with Western medicine in treatment of chronic glomerulonephritis isbetter than the routine Western medicine. However, the literature in this meta-analysis is of low quality, and the publication of the literature is biased. High quality randomized, multicenter, double-blind clinical trials will confirm it. |
| Key words: chronic glomerulonephritis Bailing capsule Meta-analysis randomized controlled trial |
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