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欧阳文;朱晓艾;刘润南;刘晓娟;粟龙杰;谢磊;曹庸;.番石榴叶具有α-葡萄糖苷酶抑制活性的倍半萜杂二醛分离与鉴定[J].湖南中医药大学学报,2014,34(8):17-20[Click to copy
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| 番石榴叶具有α-葡萄糖苷酶抑制活性的倍半萜杂二醛分离与鉴定 |
| 欧阳文;朱晓艾;刘润南;刘晓娟;粟龙杰;谢磊;曹庸; |
| (湖南中医药大学药学院; 华南农业大学食品学院) |
| 摘要: |
| 目的分离纯化番石榴叶乙酸乙酯萃取物,并对其抑制α-葡萄糖苷酶活性作用进行研究。方法采用硅胶、凝胶柱层析分离纯化,波谱法进行结构鉴定,比色法进行活性测定。结果分离得到三种倍半杂萜二醛,分别鉴定为psidials A,psiguadial A和guajadial;活性测试结果显示guajadial具有抑制α-葡萄糖苷酶活性,且显著优于阿卡波糖。结论首次报导guajadial为番石榴叶具有抑制α-葡萄糖苷酶活性的成分。 |
| 关键词: 番石榴叶 倍半萜杂二醛 分离鉴定 α-葡萄糖苷酶 |
| DOI： |
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| 基金项目:国家自然科学青年基金项目(31201321);湖南省教育厅项目(13B084);广州市科技计划项目(2013J4100075);湖南中医药大学本科教学质量工程项目(TD-007) |
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| Sesquiterpenoids with α-Glucosidase Inhibitory Activities from the Leaves of Psidium guajava Linn. |
| OU Yangwen;ZHU Xiaoai;LIU Runnan;LIU Xiaojuan;SU Longjie;XIE Lei;CAO Yong |
| (School of Pharmacy, Hunan University of Chinese Medicine;College of Food Science, South China Agricultural University) |
| Abstract: |
| (Abstracts Objective To study the a-glucosidase inhibitory active compounds from the ethyl
acetate extract of guava leaves. Methods The compounds were separated from the ethyl acetate
extract by repeating silica gel and Sephadex LH-20 column chromatography. The 'H-NMR, '3C
-NMR techniques were used to identify the chemical structures. The a-glucosidase inhibitory
activities were tested by colorimetry. Results Three special meroterpenoids were isolated and
identified as psidials A, psiguadial A and guajadial. Guajadial showed a-glucosidase inhibitory
activities significantly and its activity was better than that of Acarbose. Conclusions Guajadial as one
of the a-glucosidase inhibitory active compound from Guava leaves was reported for the first time. |
| Key words: leaves of Psidium guajava Linn. Meroterpenoids isolation and structural identification α-Glucosidase |
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