| 引用本文: |
周月,方锐,刘迅,谢乐,王玮,童骄,易亚乔,罗运花,伍大华,张堃,葛金文,彭骅.血脂、凝血功能及总胆红素与高血压合并脑白质病变的相关性分析[J].湖南中医药大学学报,2022,42(5):794-799[点击复制] |
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| 血脂、凝血功能及总胆红素与高血压合并脑白质病变的相关性分析 |
| 周月,方锐,刘迅,谢乐,王玮,童骄,易亚乔,罗运花,伍大华,张堃,葛金文,彭骅 |
| (湖南中医药大学中西医结合学院, 湖南 长沙 410208;湖南省中医药研究院附属医院, 湖南 长沙 410006;湖南中医药大学第一附属医院, 湖南 长沙 410007;常德市第一中医医院, 湖南 常德 415000;湖南中医药大学中西医结合学院, 湖南 长沙 410208;湖南省中医药研究院, 湖南 长沙 410006;长沙卫生职业学院, 湖南 长沙 410100) |
| 摘要: |
| 目的 探讨血脂、凝血功能、总胆红素与高血压(hypertension, HT)合并脑白质病变(white matter lesions, WML)程度的相关性。方法 纳入2020年7月至2021年12月在湖南中医药大学第一附属医院、湖南省中医药研究院附属医院、常德市第一中医医院筛检的273例HT合并WML患者，根据核磁结果与Fazekas量表评分将WML程度分为轻、中、重度，采集患者人口学资料，检测血压、血脂、凝血功能、总胆红素；通过单因素方差分析、非参数检验比较不同分级WML患者血脂、凝血功能、总胆红素间的差异，Logistic回归分析二者之间的相关性。结果 HT合并轻度WML患者的年龄显著低于合并中、重度WML患者(P<0.05)；文化程度和饮酒影响HT合并WML的分级(P<0.01)。HT合并轻度WML患者的凝血酶原时间(prothrombin time, PT)显著低于HT合并重度WML患者，而活化部分凝血活酶时间(activated partial thrombin time, APTT)显著高于HT合并中、重度者(P<0.05)，3组间其余检测指标无统计学差异。二分类Logistic回归分析表明，年龄、APTT、文化程度与HT合并WML的严重程度存在相关性。结论 年龄、APTT、文化程度可能是HT合并WML严重程度的独立危险因素，监测凝血功能相关指标可以作为初筛或诊断HT合并WML病情的辅助手段之一。 |
| 关键词: 高血压 脑白质病变 血脂 凝血 总胆红素 |
| DOI：10.3969/j.issn.1674-070X.2022.05.017 |
| 投稿时间：2021-12-07 |
| 基金项目:国家重点研发计划（2018YFC1704904）；湖南省重点研发计划（2020SK2016）；湖南省教育厅科学研究项目（20B436）；湖南省卫生健康委科研计划项目（202103102090）；湖南省教育厅科学研究项目（18A206）；湖南中医药大学中西医结合一流学科开放基金（2020ZXYJH27）。 |
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| Correlation analysis of blood lipid, coagulation function and total bilirubin with hypertension combined with white matter lesions |
| ZHOU Yue,FANG Rui,LIU Xun,XIE Le,WANG Wei,TONG Jiao,YI Yaqiao,LUO Yunhua,WU Dahua,ZHANG Kun,GE Jinwen,PENG Hua |
| (College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Academy of Chinese Medicine Affiliated Hospital, Changsha, Hunan 410006, China;The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan 410007, China;The First Chinese Medicine Hospital of Changde, Changde, Hunan 415000, China;College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China;Hunan Academy of Chinese Medicine, Changsha, Hunan 410006, China;Changsha Health Vocational College, Changsha, Hunan 410100, China) |
| Abstract: |
| Objective To investigate the relationship between blood lipid, coagulation function, total bilirubin and the degree of hypertension (HT) combined with white matter lesions (WML). Methods 273 patients with HT combined with WML who were screened in The First Affiliated Hospital of Hunan University of Chinese Medicine, Hunan Academy of Chinese Medicine Affiliated Hospital and The First Chinese Medicine Hospital of Changde from July 2020 to December 2021. According to MRI imaging results and Fazekas scale score, WML was divided into mild, moderate and severe WML. Demographic data of patients were collected to detect blood pressure, blood lipids, coagulation function and total bilirubin. The differences of blood lipid, coagulation function and total bilirubin in patients with different grades of VML were compared by one-way ANOVA and non-parametric test, and the correlation between them was analyzed by Logistic regression analysis. Results The age of patients with HT complicated with mild WML was significantly lower than that of patients with moderate or severe WML (P<0.05); education level and alcohol consumption influence the classification of HT combined with WML (P<0.01). Prothrombin time (PT) in patients with HT combined with mild WML was significantly lower than that in patients with HT combined with severe WML, while activated partial thrombin time (APTT) was significantly higher than that in patients with HT combined with moderate or severe WML (P<0.05), other laboratory tests showed no statistical difference among the three groups. Binary Logistic regression analysis showed that age, APTT and education level were correlated with the severity of HT combined with WML. Conclusion Age, APTT and education level may be independent risk factors for the severity of HT combined with WML, and monitoring indicators related to coagulation function may be one of the supplementary means to screen and diagnose the disease of HT combined with WML. |
| Key words: hypertension white matter lesions blood lipid blood coagulation total bilirubin |
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