| 引用本文: |
齐瑞丽,邱鸣寒,赵轩竹,何国平,梅汉玮,王华庆.淋巴瘤中医证型与预后因素相关性研究[J].湖南中医药大学学报,2022,42(4):659-664[点击复制] |
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| 淋巴瘤中医证型与预后因素相关性研究 |
| 齐瑞丽,邱鸣寒,赵轩竹,何国平,梅汉玮,王华庆 |
| (天津市人民医院肿瘤3科, 天津 300121;河南中医药大学第一附属医院, 河南 郑州 450000;天津市人民医院肿瘤3科, 天津 300121;南开大学人民医院转化医学研究院, 天津 300121) |
| 摘要: |
| 目的 探究淋巴瘤中医证型分布及证型与预后因素的相关性。方法 收集2019年7月1日至2021年2月1日南开大学人民医院就诊的淋巴瘤患者，应用SPSS 26.0软件将收集到的证型进行频次分析，并分析中医证型与患者性别、年龄、BMI、淋巴瘤病理类型、临床分期、疾病病程、治疗阶段、Ki-67、β2-MG、LDH及B症状的相关性。结果 154例患者完成入组，常见证型为瘀血内阻证、痰湿凝结证、虚实夹杂证等；与热毒内结证相比，瘀血内阻证与BMI、Ki-67、男性，痰瘀互结证与病程、病理类型，气血两虚证与BMI、Ki-67，痰湿凝结证与病理类型有较强的关联性。结论 淋巴瘤类型以弥漫大B细胞淋巴瘤、滤泡淋巴瘤、霍奇金淋巴瘤为主，且以复发/难治的中老年患者居多，常见瘀血内阻证、痰湿凝结证等证型；性别、BMI、Ki-67、病理类型、病程等客观指标有望成为淋巴瘤中医辨证分型的辅助指标。 |
| 关键词: 淋巴瘤 中医 证型 预后因素 相关性分析 |
| DOI：10.3969/j.issn.1674－070X.2022.04.023 |
| 投稿时间：2021-09-01 |
| 基金项目:国家自然科学基金面上项目（82070206）；天津市医学重点学科（专科）建设项目；天津市人民医院院内课题（2019YJ006）。 |
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| Preliminary study on the correlation between TCM syndrome types and prognostic factors of lymphoma |
| QI Ruili,QIU Minghan,ZHAO Xuanzhu,HE Guoping,MEI Hanwei,WANG Huaqing |
| (The Department of Medical Oncology, Tianjin Union Medical Center, Tianjin 300121, China;The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, Henan 450000, China;The Department of Medical Oncology, Tianjin Union Medical Center, Tianjin 300121, China;Institute of Translational Medicine, People's Hospital of Nankai University, Tianjin 300121, China) |
| Abstract: |
| Objective To explore the distribution of TCM syndrome types of lymphoma and the correlation between syndrome types and prognostic factors. Methods The patients with lymphoma treated in People's Hospital of Nankai University from July 1, 2019 to February 1, 2021 were collected. The frequency of the collected syndrome types were analyzed by SPSS 26.0 software. The relationship between TCM syndrome types and patients' gender, age, BMI, lymphoma pathological type, clinical stage, disease course, treatment stage, Ki-67, β2-MG, LDH and B symptoms was analyzed. Results 154 patients were enrolled. The common syndrome types were blood stasis internal obstruction syndrome, phlegm dampness congealing syndrome, deficiency and excess mixed syndrome; compared with heat toxin syndrome, blood stasis internal obstruction syndrome with BMI, Ki-67, male, phlegm and blood stasis syndrome with course of disease, pathological type, Qi and blood deficiency syndrome with BMI, Ki-67, phlegm dampness coagulation syndrome with pathological type had strong correlation. Conclusion The main types of lymphoma are diffuse large B cell lymphoma, follicular lymphoma and hodgkin lymphoma, and most of them are relapsed or refractory in middle-aged and elderly patients; gender, BMI, Ki-67, pathological type, course of disease and other objective indicators are expected to become auxiliary indicators of TCM syndrome differentiation of lymphoma. |
| Key words: lymphoma Chinese medicine syndrome type prognostic factors correlation analysis |
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