| 引用本文: |
戴小良,郑聪,宋利梅,刘柳,张利,高旭,卢杰,向桢.南蛇藤合剂治疗强直性脊柱炎的时效性研究[J].湖南中医药大学学报,2017,37(9):992-997[点击复制] |
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| 南蛇藤合剂治疗强直性脊柱炎的时效性研究 |
| 戴小良,郑聪,宋利梅,刘柳,张利,高旭,卢杰,向桢 |
| (中国人民解放军第181医院风湿科, 广西 桂林 541002;中国人民解放军第181医院健康管理中心, 广西 桂林 541002) |
| 摘要: |
| 目的 对比研究南蛇藤合剂与柳氮磺吡啶治疗强直性脊柱炎（ankylosing spondylitis，AS）的时效性。方法 80例AS患者按1：1比例随机分为南蛇藤合剂（NST）组和柳氮磺吡啶（sulfasalazine，SASP）组，分别服用南蛇藤合剂和SASP，疗程12周，分别在治疗前和治疗后1 w、2 w、4 w、8 w、12 w记录患者症状、体征、AS活动指数（BASDAI）、Bath 强直性脊柱炎功能指数（BASFI）、红细胞沉降率（ESR）、C反应蛋白（CRP）等。结果 NST组总有效率89.74%较SASP组总有效率81.08%高（P<0.05）。两组在12 w末均能明显控制患者腰痛晨僵时间、扩胸度、指地距离、Schober试验、BASDAI、BASFI、中医证侯评分、ESR、CRP，但南蛇藤组在第1 w末即能改善上述除BASDAI、BASFI外的所有指标，与治疗前相比差异有统计学意义（P<0.05），在第2 w末能明显改善上述所有指标，与治疗前比差异有统计学意义（P<0.01）。两组在治疗后1 w、2 w、4 w、8 w、12 w组间相比，NST组明显优于SASP组（P<0.05）。结论 南蛇藤合剂起效快，作用持久，疗效优于柳氮磺吡啶。 |
| 关键词: 南蛇藤 柳氮磺吡啶直性脊柱炎 时效性 |
| DOI：10.3969/j.issn.1674-070X.2017.09.019 |
| 投稿时间：2017-01-02 |
| 基金项目:全军保健专项课题（12BJZ14）；广西桂林市科技计划项目（20150126-2-3）。 |
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| Timeliness Research of Nansheteng Mixture on Treatment of Ankylosing Spondylitis |
| DAI Xiaoliang,ZHENG Cong,SONG Limei,LIU Liu,ZHANG Li,GAO Xu,LU Jie,XIANG Zhen |
| (Department of Rheumatology, the 181 Hospital of PLA, Guilin, Guangxi 541002, China;Health Management Center, the 181th Hospital of PLA, Guilin, Guangxi 541002, China) |
| Abstract: |
| Objective To comparative study of Nansheteng (Celastrus orbiculatus Thunb) mixture with sulfasalazine treatment of ankylosing spondylitis (AS) timeliness. Methods 80 patients with AS according to the proportion of 1:1 were randomly divided into the Nansheteng mixture group (NST) and sulfasalazine (SASP) group, administrated with Nansheteng mixture and SASP, respectively, the course was for 12 weeks. The patients' symptoms, signs, AS activity index (BASDAI), Bath ankylosing spondylitis functional index (BASFI), Erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) etc. were recored after treatment of 1 w, 2 w, 4 w, 8 w, 12 w. Results The total effective rate of NST group was 89.74%, higher than that of SASP group (81.08%). After treatment of 12 w of the two groups, the waist pain, morning stiffness time, chest expansion degree, refers to the distance, the Schober test, BASDAI, BASFI, TCM syndrome score, ESR, CRP could be controled obviously, while all the mentioned indicators excluding BASDAI and BASFI in Nansheteng group could be improved at the end of 1 w, the differences before and after treatment were statistically significant (P<0.05). At the end of the 2 w, all the above indicators could be improved obviously, it was statistically significant before and after treatment (P<0.01). After treatment of 1 w, 2 w, 4 w and 8 w, 12 w, the NTS group was significantly better than the SASP group (P<0.05). Conclusion Nansheteng mixture shows fast and durable effect, which is better than that of sulfasalazine. |
| Key words: Celastrus orbiculatus Thunb sulfasalazine ankylosing spondylitis timeliness |
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